Phenotypes associated with this allele

• Allele Symbol: Rbp3^tm1Gil
• Allele Name: targeted mutation 1, Gregory I Liou
• Allele ID: MGI:2183368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbp3^tm1Gil/Rbp3^tm1Gil	involves: 129P2/OlaHsd * C57BL/6J	MGI:3039689

Genotype
MGI:3039689

hm1

• Allelic Composition: Rbp3^tm1Gil/Rbp3^tm1Gil
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal photoreceptor outer segment morphology ( J:77624 )

• outer segments are poorly oriented and only about 60% of normal length

short photoreceptor outer segment ( J:77624 )

• outer segments are short with loss or disruption of many membranous disks

retina photoreceptor degeneration ( J:57704 , J:77624 )

• photoreceptor degeneration is seen in animals raised in darkness (J:57704)

• loss of photoreceptors (J:77624)

thin retina outer nuclear layer ( J:77624 )

• thinning of the outer nuclear layer to a thickness of 6-8 cells rather than 10-11 at age 11 days

• by 1 month of age, outer nuclear layer has become thinner than at 11 days of age

abnormal eye electrophysiology ( J:77624 )

• electroretinogram response in 1 month old rats is reduced in amplitude

• a-wave amplitude is half that of normal controls

nervous system

abnormal photoreceptor outer segment morphology ( J:77624 )

• outer segments are poorly oriented and only about 60% of normal length

short photoreceptor outer segment ( J:77624 )

• outer segments are short with loss or disruption of many membranous disks

retina photoreceptor degeneration ( J:57704 , J:77624 )

• photoreceptor degeneration is seen in animals raised in darkness (J:57704)

• loss of photoreceptors (J:77624)