About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itga2tm1Ztr
targeted mutation 1, Mary M Zutter
MGI:2183401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itga2tm1Ztr/Itga2tm1Ztr involves: 129S1/Sv * 129X1/SvJ MGI:3639574
hm2
Itga2tm1Ztr/Itga2tm1Ztr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3628643


Genotype
MGI:3639574
hm1
Allelic
Composition
Itga2tm1Ztr/Itga2tm1Ztr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1Ztr mutation (0 available); any Itga2 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mildly reduced adhesion to collagen under flow is observed in an outside-in platelet activation assay
• severely defective platelet adhesion to collagen under flow is observed in an outside-in activation assay

homeostasis/metabolism
• mildly reduced adhesion to collagen under flow is observed in an outside-in platelet activation assay
• severely defective platelet adhesion to collagen under flow is observed in an outside-in activation assay




Genotype
MGI:3628643
hm2
Allelic
Composition
Itga2tm1Ztr/Itga2tm1Ztr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1Ztr mutation (0 available); any Itga2 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the branching complexity is markedly diminished

cellular
• platelets from mutant mice failed to adhere to type I collagen under static conditions nor under shear stress
• platelets from mutant mice aggregated in response to type I collagen with a significantly prolonged lag phase and a decreased rate of aggregation
• mutant mice demonstrated no defect in wound repair

integument
• the branching complexity is markedly diminished





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory