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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itga2tm1Ztr
targeted mutation 1, Mary M Zutter
MGI:2183401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itga2tm1Ztr/Itga2tm1Ztr involves: 129S1/Sv * 129X1/SvJ MGI:3639574
hm2
Itga2tm1Ztr/Itga2tm1Ztr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3628643


Genotype
MGI:3639574
hm1
Allelic
Composition
Itga2tm1Ztr/Itga2tm1Ztr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1Ztr mutation (0 available); any Itga2 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mildly reduced adhesion to collagen under flow is observed in an outside-in platelet activation assay
• severely defective platelet adhesion to collagen under flow is observed in an outside-in activation assay

homeostasis/metabolism
• mildly reduced adhesion to collagen under flow is observed in an outside-in platelet activation assay
• severely defective platelet adhesion to collagen under flow is observed in an outside-in activation assay




Genotype
MGI:3628643
hm2
Allelic
Composition
Itga2tm1Ztr/Itga2tm1Ztr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1Ztr mutation (0 available); any Itga2 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the branching complexity is markedly diminished

cellular
• platelets from mutant mice failed to adhere to type I collagen under static conditions nor under shear stress
• platelets from mutant mice aggregated in response to type I collagen with a significantly prolonged lag phase and a decreased rate of aggregation
• mutant mice demonstrated no defect in wound repair

integument
• the branching complexity is markedly diminished





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory