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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vdrtm1Gcm
targeted mutation 1, Geert Carmeliet
MGI:2183407
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Vdrtm1Gcm/Vdrtm1Gcm
Tg(Col2a1-cre)1Bhr/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3813812


Genotype
MGI:3813812
cn1
Allelic
Composition
Vdrtm1Gcm/Vdrtm1Gcm
Tg(Col2a1-cre)1Bhr/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col2a1-cre)1Bhr mutation (3 available)
Vdrtm1Gcm mutation (0 available); any Vdr mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• osteoclast numbers in the primary ossification centers of E15.5 tibiae are reduced by two-thirds
• the number of osteoblasts found at the border of the tibiae growth plate is decreased by 50%
• the osteoclast surface area in trabecular bone in 15 day old mice is decreased by a third
• there is a 50% increase in trabecular bone volume in neonates and in 15 day old mice
• the trabecular bone extends more deeply into the metaphyseal area of the proximal tibiae in 15 day old mice
• the growth plate of cancellous bone has less blood vessel invasion and fewer osteoblasts associated with it
• trabecular ossification is delayed with smaller ossification centers occurring in the tibiae of E15.5 mice

homeostasis/metabolism
• mean serum levels of the active form of vitamin D are 127.4 pg/ml compared to 74.88 pg/ml in wild-type mice at 15 days of age
• levels normalize by adulthood
• levels of circulating FGF23, which regulates phosphate homeostasis, is decreased by 43% in 15 day old mice compared to wild-type controls
• levels normalize by adulthood
• phosphate levels are 14.33 mg/ml compared to 12.87 mg/ml in wild-type controls at 15 days of age
• levels normalize by adulthood

hematopoietic system
• osteoclast numbers in the primary ossification centers of E15.5 tibiae are reduced by two-thirds
• the number of osteoblasts found at the border of the tibiae growth plate is decreased by 50%
• the osteoclast surface area in trabecular bone in 15 day old mice is decreased by a third

cardiovascular system
• invasion of blood vessels from the perichondrium into the cartilage core is reduced by a third in tibiae growth plate of E15.5 mice
• in neonatal tibiae, the number of blood vessels invading the terminal row of the hypertrophic chondrocytes of the growth plate is reduced
• the intercapillary distance is significantly increased both at the terminal row of the growth plate and in the metaphysis of 15 day old mice

immune system
• osteoclast numbers in the primary ossification centers of E15.5 tibiae are reduced by two-thirds
• the number of osteoblasts found at the border of the tibiae growth plate is decreased by 50%
• the osteoclast surface area in trabecular bone in 15 day old mice is decreased by a third





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory