Phenotypes associated with this allele

• Allele Symbol: Alppl2^tm1Jlm
• Allele Name: targeted mutation 1, Jose Luis Millan
• Allele ID: MGI:2183412
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alppl2^tm1Jlm/Alppl2^tm1Jlm	129P3.Cg-Alppl2^tm1Jlm	MGI:3046855
hm2	Alppl2^tm1Jlm/Alppl2^tm1Jlm	either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * FVB/N)	MGI:2654849

Genotype
MGI:3046855

hm1

• Allelic Composition: Alppl2^tm1Jlm/Alppl2^tm1Jlm
• Genetic Background: 129P3.Cg-Alppl2^tm1Jlm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:61392 )

• incomplete penetrance; fewer homozygous embryos survived until the blastocyst stage; in vitro studies demonstrated a 62% mortality at 96 hours after hCG injection

embryo

abnormal preimplantation embryo development ( J:61392 )

• higher rates of degeneration during in vitro preimplantation development

embryonic growth retardation ( J:61392 )

• fewer homozygous embryos survived until the blastocyst stage and those that did survive developed more slowly than controls

reproductive system

long gestation period ( J:61392 )

♀ • the average gestational length was 12.72 hours longer than controls

decreased litter size ( J:61392 )

• the average litter size was reduced from 6.29 +/- 1.1 to 4.64 +/- 1.6 pups

growth/size/body

embryonic growth retardation ( J:61392 )

• fewer homozygous embryos survived until the blastocyst stage and those that did survive developed more slowly than controls

Genotype
MGI:2654849

hm2

• Allelic Composition: Alppl2^tm1Jlm/Alppl2^tm1Jlm
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * FVB/N)

normal phenotype

no abnormal phenotype detected ( J:39015 )

• mice have no apparent abnormalities when bred into the C57BL/6J or FVB/N backgrounds