Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nefhtm1Ral targeted mutation 1, Robert A Lazzarini MGI:2183425 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• central and peripheral nervous system development is normal
|
|
• myelinated axons are smaller than normal
• mice have fewer large diameter axons than in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Lumbar root axon abnormalities in Nefmtm1Ral/Nefmtm1Ral and Nefhtm1Ral/Nefhtm1Ral Nefmtm1Ral/Nefmtm1Ral mice, but not Nefhtm1Ral/Nefhtm1Ral mice
|
• myelinated axons are smaller than normal
• at at 2 years, axonal diameter of ventral lumbar roots is reduced within 10% of wild-type; dorsal root axons appear normal
• however, the number of large diameter axons and the total number of axons are normal
|
|
• axonal degeneration is rarely observed
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• myelinated axons are smaller than normal but not as small as in homozygous mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Hind limb paralysis develops in two year old Nefmtm1Ral/Nefmtm1Ral Nefhtm1Ral/Nefhtm1Ral mice
|
• myelinated axons are smaller than normal
• myelinated axons of lumbar ventral and dorsal roots are irregular in shape and appear shrunken and collapsed unlike in wild-type mice
• occasionally ballooned axons are observed unlike in wild-type mice
• at 4 months, axonal diameters in ventral roots are decreased more than 30% unlike in wild-type mice
• at 2 years, axonal diameter in ventral roots is reduced to less than 25% of wild-type
• mice have fewer large diameter axons in ventral and dorsal roots than in wild-type mice
• however, mice have normal numbers of axons
• axons in lumbar ventral roots are devoid of neurofilaments at 2 years of age
|
|
• axonal degeneration is rarely observed
• age-associated axonal atrophy in the lumbar dorsal and ventral roots is observed after 1 year of age unlike in wild-type mice
|
|
• in 4 of 5 mice at 2 years
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
