Phenotypes associated with this allele

• Allele Symbol: Kcnj12^tm1Swz
• Allele Name: targeted mutation 1, Thomas L Schwarz
• Allele ID: MGI:2183432
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnj12^tm1Swz/Kcnj12^tm1Swz	involves: 129S1/Sv * 129X1/SvJ * FVB	MGI:3041549

Genotype
MGI:3041549

hm1

• Allelic Composition: Kcnj12^tm1Swz/Kcnj12^tm1Swz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:78077 )

N • the hearts and brains of homozygous null mice displayed no morphological or histological abnormalities

N • cerebral arteries from wild-type and homozygous null mice constricted to the same degree to intravascular pressure (80 mm Hg)

N • Ba2+-sensitive K+-induced dilations were similar in pressurized cerebral arteries from wild-type and homozygous null adult mice; both control and homozygous null arteries dilated when the extracellular K+ concentration was increased from 6 to 15 mmol/L