Phenotypes associated with this allele

• Allele Symbol: Pgf^tm1Pec
• Allele Name: targeted mutation 1, Peter Carmeliet
• Allele ID: MGI:2183459
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgf^tm1Pec/Pgf^tm1Pec	either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * Swiss)	MGI:3042269
hm2	Pgf^tm1Pec/Pgf^tm1Pec	involves: 129	MGI:3042270
hm3	Pgf^tm1Pec/Pgf^tm1Pec	involves: 129/Sv * Swiss	MGI:4429458
hm4	Pgf^tm1Pec/Pgf^tm1Pec	Not Specified	MGI:3693884

Genotype
MGI:3042269

hm1

• Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec
• Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:77481 )

• transplanted tumors are smaller and poorly vascularized particularly if both tumor and host share this gene disruption

cardiovascular system

abnormal angiogenesis ( J:77481 )

• subtle remodeling defects in retinal vessels

• fewer vessels in corpora lutea at day 4.5 of pregnancy

• reduced revascularization after myocardial infarct, 20% fewer vessels

• fewer smooth muscle coated vessels than "naked" vessels seen in wound healing

abnormal vascular permeability ( J:77877 )

• vascular leakage induced by VEGF was reduced

• reduced leakage also seen during the course of wound healing

• reduced vascular leakage as a result of delayed skin hypersensitivity

homeostasis/metabolism

delayed wound healing ( J:77481 )

• skin wounds heal more slowly

Genotype
MGI:3042270

hm2

• Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec
• Genetic Background: involves: 129

neoplasm

decreased tumor growth/size ( J:77481 )

• transplanted tumors are smaller and poorly vascularized particularly if both tumor and host share this gene disruption

cardiovascular system

abnormal angiogenesis ( J:77481 )

• subtle remodeling defects in retinal vessels

• fewer vessels in corpora lutea at day 4.5 of pregnancy

• reduced revascularization after myocardial infarct, 20% fewer vessels

• fewer smooth muscle coated vessels than "naked" vessels seen in wound healing

abnormal vascular permeability ( J:77877 )

• vascular leakage induced by VEGF was reduced

• reduced leakage also seen during the course of wound healing

• reduced vascular leakage as a result of delayed skin hypersensitivity

immune system

decreased susceptibility to type IV hypersensitivity reaction ( J:81388 )

• delayed-type hypersensitivity reactions reduced

• reduced edema

• reduced infiltration of inflammatory cells

homeostasis/metabolism

delayed wound healing ( J:77481 )

• skin wounds heal more slowly

Genotype
MGI:4429458

hm3

• Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec
• Genetic Background: involves: 129/Sv * Swiss

growth/size/body

decreased birth weight ( J:116580 )

• significantly reduced

• weight normal at 15 weeks when fed a standard diet

decreased susceptibility to weight gain ( J:116580 )

• reduced weight gain on a high fat diet relative to controls

embryo

decreased placenta weight ( J:116580 )

adipose tissue

abnormal adipose tissue morphology ( J:116580 )

• blood vessel density in adipose tissue is lower than in controls

decreased subcutaneous adipose tissue amount ( J:116580 )

• significantly reduced

decreased total body fat amount ( J:116580 )

• total body fat is reduced

decreased fat cell size ( J:116580 )

• slightly reduced in size

decreased gonadal fat pad weight ( J:116580 )

• significantly reduced

• smaller blood vessel size

integument

decreased subcutaneous adipose tissue amount ( J:116580 )

• significantly reduced

Genotype
MGI:3693884

hm4

• Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec
• Genetic Background: Not Specified

vision/eye

cornea vascularization ( J:114973 )

• corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

cardiovascular system

cornea vascularization ( J:114973 )

• corneal injection of a plasmid encoding short hairpin RNA targeting secreted Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

respiratory system

respiratory system phenotype ( J:77480 )

N • normal pulmonary development