Phenotypes associated with this allele

• Allele Symbol: Scn8a^4J
• Allele Name: 4 Jackson
• Allele ID: MGI:2183462
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn8a^4J/Scn8a^4J	C57BL/6J-Scn8a^4J/J	MGI:2183463

Genotype
MGI:2183463

hm1

• Allelic Composition: Scn8a^4J/Scn8a^4J
• Genetic Background: C57BL/6J-Scn8a^4J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:78134 , J:90095 )

• mice die between 3 and 5 weeks of age (J:78134)

behavior/neurological

hindlimb paralysis ( J:78134 )

• loss of the use of hindlimbs bilaterally is evident between 13-18 days

• standard pathological workup on 4 mutants (age 18-19 days) showed no muscle atrophy or necrosis; additional histology of hindlimb muscles showed no evidence of reinnervation/regeneration and normal neuromuscular junction morphology in all mice

growth/size/body

decreased body size ( J:78134 )

• mutant mice are described as small