Phenotypes associated with this allele

• Allele Symbol: Ankfn1^nmf9
• Allele Name: neuroscience mutagenesis facility, 9
• Allele ID: MGI:2183465
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankfn1^nmf9/Ankfn1^nmf9	C57BL/6J-Ankfn1^nmf9/J	MGI:2183466

Genotype
MGI:2183466

hm1

• Allelic Composition: Ankfn1^nmf9/Ankfn1^nmf9
• Genetic Background: C57BL/6J-Ankfn1^nmf9/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:221935 )

N • mice exhibit normal performance in a marble burying test and food consumption

abnormal behavior ( J:221935 )

• mice exhibit abnormal the landing test with increased frequency of trunk curling and rotation

impaired conditioned place preference behavior ( J:221935 )

• more severe in female than male mice

impaired cued conditioning behavior ( J:221935 )

• more severe in female than male mice

tremors ( J:221935 )

• enhanced by light vertical acceleration or extended handling

• however, the tremor phenotype do not worsen with time

impaired swimming ( J:221935 )

• unable to remain righted above the surface

head bobbing ( J:78134 , J:221935 )

• visible phenotype appears by weaning age as variable but generally subtle head-nodding (J:78134)

• severity increases progressively from 21 days to 6 months (J:221935)

• head nodding is enhanced by light vertical acceleration or extended handling (J:221935)

head tilt ( J:221935 )

hyperactivity ( J:221935 )

• enhanced by light vertical acceleration or extended handling

• however, hyperactivity is does not worsen with time and does not affect activity counts in circadian rhythm tests

circling ( J:221935 )

• severity increases progressively from 21 days to 6 months

abnormal circadian behavior ( J:221935 )

• most severely affected mice exhibit less consolidation of activity into nighttime hours compared with wild-type mice

• however, hyperactivity does not affect activity counts

abnormal circadian behavior period ( J:221935 )

• increased onset error in total darkness

shortened circadian behavior period ( J:221935 )

• slight in total darkness

growth/size/body

decreased body weight ( J:221935 )

• slight at 2 to 6 months without a change in food consumption

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:221935 )

N • mice exhibit normal grossly normal inner ear structures and normal hearing

abnormal vestibular system physiology ( J:221935 )

• vestibular phenotypes are more severe in female than male mice

taste/olfaction

taste/olfaction phenotype ( J:221935 )

N • mice exhibit normal olfaction