Phenotypes associated with this allele

• Allele Symbol: Fancg^tm1Faw
• Allele Name: targeted mutation 1, Fre Arwert
• Allele ID: MGI:2183473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fancg^tm1Faw/Fancg^tm1Faw	involves: 129P2/OlaHsd * FVB/N	MGI:3621178

Genotype
MGI:3621178

hm1

• Allelic Composition: Fancg^tm1Faw/Fancg^tm1Faw
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:74737 )

♀

abnormal ovarian folliculogenesis ( J:74737 )

♀ • fewer developing follicles than found in control mice

small ovary ( J:74737 )

♀

abnormal seminiferous tubule morphology ( J:74737 )

♂

increased Leydig cell number ( J:74737 )

♂

small testis ( J:74737 )

♂

reproductive system

abnormal ovary morphology ( J:74737 )

♀

abnormal ovarian folliculogenesis ( J:74737 )

♀ • fewer developing follicles than found in control mice

small ovary ( J:74737 )

♀

abnormal seminiferous tubule morphology ( J:74737 )

♂

increased Leydig cell number ( J:74737 )

♂

small testis ( J:74737 )

♂

abnormal spermiogenesis ( J:74737 )

♂ • multiple sperm heads are conjoined; few sperm develop as individual spermatozoa

reduced female fertility ( J:74737 )

♀ • females stopped breeding by 21 weeks of age

♀ • litter sizes are smaller than produced by control mice

reduced male fertility ( J:74737 )

♂ • males stopped breeding by 29 weeks of age

♂ • litter sizes are smaller than produced by control mice

cellular

chromosome breakage ( J:74737 )

induced chromosome breakage ( J:74737 )

• embryonic fibroblasts, in vitro, show hyper-responsiveness to antiproliferative effects of mitomycin C

spontaneous chromosome breakage ( J:74737 )

• embryonic fibroblasts from mutant mice, in vitro, show enhanced spontaneous chromosomal instability