Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mdm4tm1Glo targeted mutation 1, Guillermina Lozano MGI:2183485 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die as early as E7.5
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• at E7.5, embryos exhibit decreased cellular proliferation compared with wild-type embryos without an increase in apoptosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with ionizing radiation exhibit increased mortality compared with similarly treated wild-type mice and Mdm2tm1Glo heterozygotes
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• following transformation with c-myc and activated Ras oncogenes, mouse embryonic fibroblasts exhibit 33% fewer foci compared with wild-type cells
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• mice treated with ionizing radiation exhibit increased mortality compared with similarly treated wild-type mice and Mdm2tm1Glo heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 65% of mice die after exposure to 6 Gy of ionizing radiation
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• starting around 3 - 4 weeks of age
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• starting around 3 - 4 weeks of age
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• starting around 3 - 4 weeks of age
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• 65% of mice die after exposure to 6 Gy of ionizing radiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are born in expected Mendelian ratios
(J:71532)
• mice are born in expected Mendelian ratios
(J:93838)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present at 3 weeks of age
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• embryos are abnormal at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal mortality in response to treatment with ionizing radiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die within 3 months
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• decreased compared to Trp53tm1.1Tldo/+ mice
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• decreased compared to Trp53tm1.1Tldo/+ mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present at 3 weeks of age
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• embryos are abnormal at E9.5
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• at E9.5
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• at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present at weaning
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• fewer than expected mice are born
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• mice exhibit decreased extramedullary hematopoiesis in the liver
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• hypoplastic
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• disorganized
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• the granule layer of the cerebellum is hypoplastic with defects in both the external granule layer and the internal granule layer
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• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails
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• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails
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• mid-gestation
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• mice are smaller than normal at birth
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• following transformation with c-myc and activated Ras oncogenes, mouse embryonic fibroblasts exhibit fewer foci compared with wild-type or single heterozygote cells
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• in E13.5 embryos
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• fewer and smaller
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• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails
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• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails
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• in E13.5 embryos
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• mid-gestation
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• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop B cell lymphomas
• however, lymphomagenesis is delayed compared to in Tg(IghMyc)22Bri mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are born in expected Mendelian ratios
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• bone marrow sections show hypocellularity indicative of aplastic anemia
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• distribution of Purkinje neurons is disorganized in the cerebellum
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• detectable first at P4
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• detectable first at P4
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• detectable first at P4
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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