cellular
• mutation rates at CpGs in increased relative to wild-type rates with CG to TA being the most common mutation and occurring 3.3-fold more than in wild-type mice
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Allele Symbol Allele Name Allele ID |
Mbd4tm1Bird targeted mutation 1, Adrian Bird MGI:2183491 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mutation rates at CpGs in increased relative to wild-type rates with CG to TA being the most common mutation and occurring 3.3-fold more than in wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit reduced survival
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• mice had a greater intestinal adenoma burden at death with a median of 28 tumors compared to Mbd4tm1Bird ApcMin heterozygotes (median of 14 tumors at time of death)
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• repair of C to T transitions is reduced to 88% efficiency from 96% in Mbd4tm1Bird ApcMin heterozygotes
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• repair of C to T transitions is reduced to 88% efficiency from 96% in Mbd4tm1Bird ApcMin heterozygotes
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• mice had a greater intestinal adenoma burden at death with a median of 28 tumors compared to Mbd4tm1Bird ApcMin heterozygotes (median of 14 tumors at time of death)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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