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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pth1rtm2Hmk
targeted mutation 2, Henry M Kronenberg
MGI:2183512
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ihhtm1Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB MGI:3584276
cn2
 		Ihhtm1Amc/Ihhtm2Amc
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB MGI:3584278
cn3
 		Pthlhtm1Hmk/Pthlh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N MGI:3584345
cn4
 		Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Tg(Col2a1-PTHLH)1Ecw/0 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL MGI:3584347
cn5
 		Ihhtm2Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N MGI:3584277
cn6
 		Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Dmp1-cre/ERT2)0022Pdp/0 		involves: 129S4/SvJae * C3H * C57BL/6 MGI:5297558
cn7
 		Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:3584275
cn8
 		Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:3584049
cn9
 		Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Col2a1-cre)1Rsjo/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3584040
cx10
 		Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Col2a1-PTHLH)1Ecw/0 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * SJL MGI:3584346


Genotype
MGI:3584276
cn1
Allelic
Composition		 Ihhtm1Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased long bone epiphyseal plate size ( J:99641 )
• growth plate is expanded, however less than in compound heterozygous mice that contain Ihh




Genotype
MGI:3584278
cn2
Allelic
Composition		 Ihhtm1Amc/Ihhtm2Amc
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Ihhtm2Amc mutation (0 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal chondrocyte differentiation ( J:99641 )
• ectopic hypertrophic differentiation in growth plates, however do not observe elongation of the columnar region




Genotype
MGI:3584345
cn3
Allelic
Composition		 Pthlhtm1Hmk/Pthlh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased long bone epiphyseal plate size ( J:99641 )
• growth plate is shorted by about 8%




Genotype
MGI:3584347
cn4
Allelic
Composition		 Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Tg(Col2a1-PTHLH)1Ecw/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
Tg(Col2a1-PTHLH)1Ecw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
long tibia ( J:99641 )
• increase in tibia length
abnormal long bone epiphyseal plate morphology ( J:99641 )
• exhibit ectopically differentiated chondrocytes
abnormal chondrocyte differentiation ( J:99641 )
• eutopic hypertrophic chondrocyte differentiation is stimulated

limbs/digits/tail
long tibia ( J:99641 )
• increase in tibia length




Genotype
MGI:3584277
cn5
Allelic
Composition		 Ihhtm2Amc/Ihh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm2Amc mutation (0 available); any Ihh mutation (22 available)
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone hypertrophic chondrocyte zone ( J:99641 )
• elongation of the columnar region
abnormal chondrocyte differentiation ( J:99641 )
• ectopic hypertrophic differentiation in growth plates




Genotype
MGI:5297558
cn6
Allelic
Composition		 Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Dmp1-cre/ERT2)0022Pdp/0
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Dmp1-cre/ERT2)0022Pdp mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:170229 )
N
• tamoxifen-treated adult mice have relatively normal rates of bone modeling and remodeling
decreased bone mineral density of vertebrae ( J:170229 )
• vertebral bone mineral density is signifiincantly reduced in tamoxifen-treated adult females; a similar trend is observed in males but is not statistically significant
decreased bone mineral density of femur ( J:170229 )
• femoral bone mineral density is signifiincantly reduced in tamoxifen-treated adult females; a similar trend is observed in males but is not statistically significant
abnormal trabecular bone morphology ( J:170229 )
• tibia of tamoxifen-treated adult mice exhibit reduction in trabecular bone and a delay in the secondary ossification center




Genotype
MGI:3584275
cn7
Allelic
Composition		 Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:99641 )
• chondrocytes prematurely differentiate into hypertrophic chondrocytes in the columnar region
increased long bone epiphyseal plate size ( J:99641 )
• growth plate expansion




Genotype
MGI:3584049
cn8
Allelic
Composition		 Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Bglap2-cre)1Kry mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:77683 )
• develop ectopic hypertrophy in the columnar region of tibia due to premature hypertrophic differentiation
abnormal long bone hypertrophic chondrocyte zone ( J:77683 )
• periarticular chondrocyte differentiation into columnar cells is accelerated




Genotype
MGI:3584040
cn9
Allelic
Composition		 Pth1rtm2Hmk/Pth1rtm2Hmk
Tg(Col2a1-cre)1Rsjo/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Tg(Col2a1-cre)1Rsjo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased long bone epiphyseal plate size ( J:77683 )
• tibial growth plate is shortened
• the periarticular and columnar regions are reduced despite increased proliferation in the periarticular region
abnormal sternum morphology ( J:77683 )
• the sternum is occupied by hypertrophic cells at E16.5
decreased chondrocyte number ( J:77683 )
• tibial growth plate lacks most of the columnar chondrocytes however the hypertrophic layer is normal
chondrodystrophy ( J:77683 )
• the tibial growth plate is shortened and lacks most of the columnar chondrocytes




Genotype
MGI:3584346
cx10
Allelic
Composition		 Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Col2a1-PTHLH)1Ecw/0
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation (0 available); any Pth1r mutation (29 available)
Pth1rtm2Hmk mutation (0 available); any Pth1r mutation (29 available)
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Col2a1-PTHLH)1Ecw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:99641 )
• rescued growth plate lacks hypertrophic chondrocytes and columnar cells
abnormal bone ossification ( J:99641 )
• bone formation is suppressed

limbs/digits/tail

immune system
abnormal bone marrow development ( J:99641 )
• bone marrow formation is suppressed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory