Phenotypes associated with this allele

• Allele Symbol: Pth1r^tm3Hmk
• Allele Name: targeted mutation 3, Henry M Kronenberg
• Allele ID: MGI:2183514
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pth1r^tm3Hmk/Pth1r^tm3Hmk	involves: 129S4/SvJae * C57BL/6	MGI:3584051
ht2	Pth1r^tm1Hmk/Pth1r^tm3Hmk	involves: 129S4/SvJae * C57BL/6	MGI:3584042
cx3	Pth1r^tm1Hmk/Pth1r^tm3Hmk Tg(Col2a1-PTHR1*H223R)AHju/?	involves: 129S4/SvJae * C57BL/6	MGI:3584046

Genotype
MGI:3584051

hm1

• Allelic Composition: Pth1r^tm3Hmk/Pth1r^tm3Hmk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone epiphyseal plate morphology ( J:77683 )

• slightly abnormal growth plates

• exhibit milder phenotypes than compound heterozygous Phthr1^tm1Hmk and Phthr1^tm3Hmk mutant mice

Genotype
MGI:3584042

ht2

• Allelic Composition: Pth1r^tm1Hmk/Pth1r^tm3Hmk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

growth/size/body

postnatal growth retardation ( J:77683 )

• begins around 7 days of age

limbs/digits/tail

abnormal limb morphology ( J:77683 )

• start to show limb deformities around 7 days of age

long tibia ( J:77683 )

• slightly greater total length of tibiae

skeleton

long tibia ( J:77683 )

• slightly greater total length of tibiae

abnormal long bone epiphyseal plate morphology ( J:77683 )

• slightly smaller columnar and periarticular regions of growth plates and greater growth plates than in controls

abnormal long bone hypertrophic chondrocyte zone ( J:77683 )

• hypertrophic layer expansion in E17.5 tibial growth plates and prehypertrophic domain expansion due to an increase in early hypertrophic cells

premature chondrocyte differentiation ( J:77683 )

• early chondrocyte differentiation is accelerated as indicated by increased numbers of proliferating hypertrophic chondrocytes and decreased numbers of proliferating columnar chondrocytes

Genotype
MGI:3584046

cx3

• Allelic Composition: Pth1r^tm1Hmk/Pth1r^tm3Hmk; Tg(Col2a1-PTHR1*H223R)AHju/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

skeleton

abnormal long bone hypertrophic chondrocyte zone ( J:77683 )

• expansion of fully differentiated hypertrophic chondrocytes in tibia