Phenotypes associated with this allele

• Allele Symbol: Gapdh^m1Neu
• Allele Name: mutation 1, Neuherberg
• Allele ID: MGI:2183515
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gapdh^m1Neu/Gapdh^m1Neu	C3.Cg-Gapdh^m1Neu	MGI:3808728
hm2	Gapdh^m1Neu/Gapdh^m1Neu	involves: 101/El * C3H/El	MGI:3663923
ht3	Gapdh^m1Neu/Gapdh^+	C3.Cg-Gapdh^m1Neu	MGI:3808729
ht4	Gapdh^m1Neu/Gapdh^+	involves: 101/El * C3H/El	MGI:3663924

Genotype
MGI:3808728

hm1

• Allelic Composition: Gapdh^m1Neu/Gapdh^m1Neu
• Genetic Background: C3.Cg-Gapdh^m1Neu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:126359 )

• number of live implantations is reduced by around 17%, compared to wild-type, suggesting lethality occurs shortly after implantation

Genotype
MGI:3663923

hm2

• Allelic Composition: Gapdh^m1Neu/Gapdh^m1Neu
• Genetic Background: involves: 101/El * C3H/El

mortality/aging

preweaning lethality, complete penetrance ( J:11216 , J:15477 )

• homozygotes are not detected but time point of examination is not given (J:15477)

Genotype
MGI:3808729

ht3

• Allelic Composition: Gapdh^m1Neu/Gapdh⁺
• Genetic Background: C3.Cg-Gapdh^m1Neu

homeostasis/metabolism

decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ( J:126359 )

• Gapdh activity is approximately 50-55% of wild-type levels

Genotype
MGI:3663924

ht4

• Allelic Composition: Gapdh^m1Neu/Gapdh⁺
• Genetic Background: involves: 101/El * C3H/El

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:15477 )

• the original mutant showed a 75% erythrocyte enzyme activity but subsequent generations show 50% activity