Phenotypes associated with this allele

• Allele Symbol: Fgfr2^tm2.1Lni
• Allele Name: targeted mutation 2.1, Peter Lonai
• Allele ID: MGI:2183527
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^tm2.1Lni/Fgfr2^tm2.1Lni	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:3844308
hm2	Fgfr2^tm2.1Lni/Fgfr2^tm2.1Lni	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3766095

Genotype
MGI:3844308

hm1

• Allelic Composition: Fgfr2^tm2.1Lni/Fgfr2^tm2.1Lni
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:77698 )

respiratory system

absent lungs ( J:77698 )

limbs/digits/tail

absent limbs ( J:77698 )

endocrine/exocrine glands

absent submandibular gland ( J:77698 )

• agenesis

digestive/alimentary system

absent submandibular gland ( J:77698 )

• agenesis

Genotype
MGI:3766095

hm2

• Allelic Composition: Fgfr2^tm2.1Lni/Fgfr2^tm2.1Lni
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:126496 )

• mutants die at birth due to lung defects

nervous system

abnormal synaptic vesicle number ( J:126496 )

• increased density of vesicles in distal nerve branches near synaptic sites but minimal in proximal regions and in main nerve trunks

abnormal synaptic vesicle clustering ( J:126496 )

• by E16, vesicles were less restricted to synaptic sites than in controls

• axons entered muscles normally and arborized at AChR-rich sites