All Phenotypes Fgfr2<tm3.1Lni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^tm3.1Lni/Fgfr2^tm3.1Lni	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:3844310
cn2	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm3.1Lni/Fgfr2^tm3.1Lni Tg(Pax3-cre)1Joe/0	involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL	MGI:5438679
cx3	Fgfr2^tm3.1Lni/Fgfr2⁺ Hmgcs2^em1Wilh/Hmgcs2^em1Wilh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6416132

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal osteoblast proliferation ( J:77698 )

• proliferation of osteoblasts is prematurely lost compared to in wild-type mice

skeleton

abnormal osteoblast proliferation ( J:77698 )

• proliferation of osteoblasts is prematurely lost compared to in wild-type mice

abnormal coronal suture morphology ( J:77698 )

• at E16.5 and P1, cell proliferation at the coronal suture is decreased compared to in wild-type mice

• proliferation of osteoblasts is prematurely lost compared to in wild-type mice

abnormal nasomaxillary suture morphology ( J:77698 )

• mice exhibit a down-curved nasomaxillary region unlike wild-type mice

abnormal basicranium morphology ( J:77698 )

• from E15.5 to P14, the bones in the skull base are reduced in size compared to in wild-type mice

• at P14, the ratio of bone lengths is 1:0.95 from the outer border of the exoccipital bone to the basioccipital-sphenoid suture, but 1:0.55 from this suture to the caudal border of the maxilla

• the distance between the otic capsule and the caudal border of the tooth row is reduced compared to in wild-type mice

decreased cranium height ( J:77698 )

abnormal sphenoid bone morphology ( J:77698 )

• the sphenoid region of the skull base exhibit reduced growth compared to in wild-type mice

abnormal basisphenoid bone morphology ( J:77698 )

• at P14, the basisphenoid-presphenoid suture is abnormally positioned under the bony plate unlike in wild-type mice

abnormal presphenoid bone morphology ( J:77698 )

• at P14, the basisphenoid-presphenoid suture is abnormally positioned under the bony plate unlike in wild-type mice

domed cranium ( J:77698 )

decreased width of hypertrophic chondrocyte zone ( J:77698 )

premature cranial suture closure ( J:77698 )

• at P14, mice exhibit premature fusion of the basioccipital and exoccipital bones and between the exoccipital and supraoccipital bones unlike in wild-type mice

• synostoses between cranial sutures at P14

premature coronal suture closure ( J:77698 )

• at P14, the coronal suture is partially or completely fused unlike in wild-type mice

delayed bone ossification ( J:77698 )

• at E14.5, only mandible, clavicle, scapula, humerus, and proximal parts of the upper ribs are ossified

• at E14.5, the dermal and endochondral components of the skull vault and skull base exhibit delayed ossification compared to in wild-type mice

• at E14.5, there is no ossification of the hind limb or vertebrae unlike in wild-type mice

• at P14, the vertebral arches are not fused along the dorsal midline as in wild-type mice

craniofacial

abnormal coronal suture morphology ( J:77698 )

• at E16.5 and P1, cell proliferation at the coronal suture is decreased compared to in wild-type mice

• proliferation of osteoblasts is prematurely lost compared to in wild-type mice

abnormal nasomaxillary suture morphology ( J:77698 )

• mice exhibit a down-curved nasomaxillary region unlike wild-type mice

abnormal basicranium morphology ( J:77698 )

• from E15.5 to P14, the bones in the skull base are reduced in size compared to in wild-type mice

• at P14, the ratio of bone lengths is 1:0.95 from the outer border of the exoccipital bone to the basioccipital-sphenoid suture, but 1:0.55 from this suture to the caudal border of the maxilla

• the distance between the otic capsule and the caudal border of the tooth row is reduced compared to in wild-type mice

decreased cranium height ( J:77698 )

abnormal sphenoid bone morphology ( J:77698 )

• the sphenoid region of the skull base exhibit reduced growth compared to in wild-type mice

abnormal basisphenoid bone morphology ( J:77698 )

• at P14, the basisphenoid-presphenoid suture is abnormally positioned under the bony plate unlike in wild-type mice

abnormal presphenoid bone morphology ( J:77698 )

• at P14, the basisphenoid-presphenoid suture is abnormally positioned under the bony plate unlike in wild-type mice

domed cranium ( J:77698 )

abnormal facial morphology ( J:77698 )

• mice exhibit shortened and sometimes bent facial areas unlike wild-type mice

growth/size/body

abnormal head morphology ( J:77698 )

abnormal facial morphology ( J:77698 )

• mice exhibit shortened and sometimes bent facial areas unlike wild-type mice

decreased body size ( J:77698 )

• mice exhibit dwarfism

decreased body weight ( J:77698 )

slow postnatal weight gain ( J:77698 )

• even before incisor eruption

postnatal growth retardation ( J:77698 )

• 40% to 50% less than in wild-type mice

vision/eye

exophthalmos ( J:77698 )

• slight

renal/urinary system

renal/urinary system phenotype ( J:167305 )

• mice exhibit normal kidney development at E13.5 and E16.5; no differences in the long axis or surface area of the total kidney are noted at E18.5 relative to controls

• no ureteric induction defects or other congenital anomalies of the kidney and urinary tract are observed

• after 48 hrs culture, E12.5 kidney explants show normal ureteric branching and nephron development

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm3.1Lni/Fgfr2^tm3.1Lni Tg(Pax3-cre)1Joe/0
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2^tm3.1Lni mutation (0 available); any Fgfr2 mutation (90 available)
Tg(Pax3-cre)1Joe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal metanephric mesenchyme morphology ( J:167305 )

• at E10.5, mice exhibit a severe reduction in the size of condensed metanephric mesenchyme relative to controls, as shown by H&E staining

• still images of 3D reconstructions show a 70% reduction in metanephric mesenchyme volume at E10.5

• at E11.5, the metanephric mesenchyme remains small and less condensed, unlike in controls

increased metanephric mesenchyme apoptosis ( J:167305 )

• by E12.5, high levels of apoptosis are noted throughout the remnant metanephric mesenchyme, as revealed by TUNEL staining

• however, no obvious differences in mesenchymal proliferation or apoptosis are noted at E10.5 and E11.5 relative to controls

absent kidney ( J:167305 )

• no apparent kidney tissues are observed at E13.5 and E18.5

impaired branching involved in ureteric bud morphogenesis ( J:167305 )

• at E11.5, ureteric buds remain unbranched, unlike in controls

abnormal ureteric bud invasion ( J:167305 )

• at E11.5, none of the ureteric buds elongate into the metanephric mesenchyme, unlike in controls

ectopic ureteric bud ( J:167305 )

• a subset of mice develop an anteriorly displaced secondary ureteric bud, unlike in controls

small ureteric bud ( J:167305 )

• at E11.5, ureteric buds are small and unbranched, unlike in controls

cellular

increased metanephric mesenchyme apoptosis ( J:167305 )

• by E12.5, high levels of apoptosis are noted throughout the remnant metanephric mesenchyme, as revealed by TUNEL staining

• however, no obvious differences in mesenchymal proliferation or apoptosis are noted at E10.5 and E11.5 relative to controls

embryo

increased metanephric mesenchyme apoptosis ( J:167305 )

• by E12.5, high levels of apoptosis are noted throughout the remnant metanephric mesenchyme, as revealed by TUNEL staining

• however, no obvious differences in mesenchymal proliferation or apoptosis are noted at E10.5 and E11.5 relative to controls

Allelic Composition	Fgfr2^tm3.1Lni/Fgfr2⁺ Hmgcs2^em1Wilh/Hmgcs2^em1Wilh
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^tm3.1Lni mutation (0 available); any Fgfr2 mutation (90 available)
Hmgcs2^em1Wilh mutation (0 available); any Hmgcs2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:285178 )

N	• testes development is similar to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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