Phenotypes associated with this allele

• Allele Symbol: Ncoa1^tm1Bwo
• Allele Name: targeted mutation 1, Bert W O'Malley
• Allele ID: MGI:2183532
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo	involves: 129 * C57BL/6	MGI:3608131
hm2	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo	involves: 129 * C57BL/6J	MGI:5002578
hm3	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo	involves: 129/Sv * C57BL/6	MGI:3527794
cn4	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Ncoa2^tm1.1Ipc/Ncoa2^tm1.1Ipc Pgr^tm2(cre)Lyd/Pgr^+	involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3716555
cx5	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thrb^tm1Olc/Thrb^tm1Olc	B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc	MGI:4358582
cx6	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thra^tm2Jas/Thra^tm2Jas	B6.129-Thra^tm2Jas Ncoa1^tm1Bwo	MGI:4358584

Genotype
MGI:3608131

hm1

• Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:101966 )

N • no lipid accumulation in sertoli cells were observed

Genotype
MGI:5002578

hm2

• Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo
• Genetic Background: involves: 129 * C57BL/6J

immune system

immune system phenotype ( J:109522 )

N • mice exhibit normal white blood cell numbers

Genotype
MGI:3527794

hm3

• Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo
• Genetic Background: involves: 129/Sv * C57BL/6

reproductive system

abnormal decidualization ( J:46528 )

♀ • less decidual response to mechanical stimulation

♀ • reduced response to estrogen treatment

abnormal female reproductive system morphology ( J:46528 )

♀

abnormal male reproductive system morphology ( J:46528 )

♂

small prostate gland ( J:46528 )

♂ • growth reduced about 34% in castrated males after testosterone treatment

small testis ( J:46528 )

♂ • smaller testes but structurally normal

♂ • 19% reduction in testis/body weight ratio

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:54182 , J:126521 )

abnormal thyroid hormone level ( J:54182 )

increased thyroxine level ( J:54182 )

increased circulating thyroxine level ( J:126521 )

increased triiodothyronine level ( J:54182 )

increased circulating triiodothyronine level ( J:126521 )

abnormal response/metabolism to endogenous compounds ( J:126521 )

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice

endocrine/exocrine glands

abnormal mammary gland development ( J:46528 )

♀ • ductal development only about half normal at 8 weeks of age

♀ • alveoli much less developed

small prostate gland ( J:46528 )

♂ • growth reduced about 34% in castrated males after testosterone treatment

small testis ( J:46528 )

♂ • smaller testes but structurally normal

♂ • 19% reduction in testis/body weight ratio

behavior/neurological

abnormal spatial learning ( J:81201 )

• increased escape latency in a Morris water maze

• slower swim speed

impaired coordination ( J:81201 )

• tended to fall in a hanging wire test about 29% earlier than controls

• shorter latency to falling in a rotarod test and less improvement with repeated testing

nervous system

abnormal cerebellum morphology ( J:81201 )

abnormal cerebellar Purkinje cell layer ( J:81201 )

• absent at birth

• gradually reached normal levels by about age 10 days

abnormal Purkinje cell morphology ( J:81201 )

• development of Purkinje cell precursors delayed from E10.5 to around E12.5

embryo

abnormal decidualization ( J:46528 )

♀ • less decidual response to mechanical stimulation

♀ • reduced response to estrogen treatment

integument

abnormal mammary gland development ( J:46528 )

♀ • ductal development only about half normal at 8 weeks of age

♀ • alveoli much less developed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:54182

Genotype
MGI:3716555

cn4

• Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo; Ncoa2^tm1.1Ipc/Ncoa2^tm1.1Ipc; Pgr^tm2(cre)Lyd/Pgr⁺
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

reproductive system

abnormal decidualization ( J:117006 )

♀ • uterus fails to display any decidual response upon stimulation

embryo

abnormal decidualization ( J:117006 )

♀ • uterus fails to display any decidual response upon stimulation

Genotype
MGI:4358582

cx5

• Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo; Thrb^tm1Olc/Thrb^tm1Olc
• Genetic Background: B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc

homeostasis/metabolism

increased circulating thyroxine level ( J:126521 )

increased circulating triiodothyronine level ( J:126521 )

increased circulating thyroid-stimulating hormone level ( J:126521 )

• mice exhibit increased TSH levels

• after a low-iodine diet and propylthiouracil, TSH serum levels more than wild-type

abnormal response/metabolism to endogenous compounds ( J:126521 )

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit more resistance to thyroid hormone compared with wild-type mice or either single homozygote

Genotype
MGI:4358584

cx6

• Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo; Thra^tm2Jas/Thra^tm2Jas
• Genetic Background: B6.129-Thra^tm2Jas Ncoa1^tm1Bwo

homeostasis/metabolism

increased circulating thyroxine level ( J:126521 )

increased circulating triiodothyronine level ( J:126521 )

decreased circulating thyroid-stimulating hormone level ( J:126521 )

• after a low-iodine diet and propylthiouracil, TSH serum levels increase to 50% of wild-type

increased circulating thyroid-stimulating hormone level ( J:126521 )

abnormal response/metabolism to endogenous compounds ( J:126521 )

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice