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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agtr1atm2Tma
targeted mutation 2, Taiji Matsusaka
MGI:2183543
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Agtr1atm2Tma/Agtr1atm2Tma involves: 129P2/OlaHsd * C57BL/6 MGI:3656075


Genotype
MGI:3656075
hm1
Allelic
Composition		 Agtr1atm2Tma/Agtr1atm2Tma
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm2Tma mutation (0 available); any Agtr1a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney interlobular artery morphology ( J:36090 )
• interlobular artery is abnormally hypertrophic compared to wild-type
abnormal juxtaglomerular apparatus morphology ( J:36090 )
• markedly enlarged compared to wild-type
juxtaglomerular cell hyperplasia ( J:36090 )
• there are increased numbers of renin-secreting cells compared to wild-type

cardiovascular system
abnormal kidney interlobular artery morphology ( J:36090 )
• interlobular artery is abnormally hypertrophic compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory