Phenotypes associated with this allele

• Allele Symbol: Artn^tm1Jmi
• Allele Name: targeted mutation 1, Jeffrey Milbrandt
• Allele ID: MGI:2183554
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Artn^tm1Jmi/Artn^tm1Jmi	involves: 129X1/SvJ * FVB/N	MGI:2651770

Genotype
MGI:2651770

hm1

• Allelic Composition: Artn^tm1Jmi/Artn^tm1Jmi
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

blepharoptosis ( J:78008 )

• drooping eyelids seen in about 30% of adult mice

nervous system

abnormal enteric neuron morphology ( J:78008 )

• reduced numbers of sympathetic fibers in the gut

• sympathetic fibers are lost from the circular muscle layer of the esophagus, stomach, and intestine

abnormal sympathetic ganglion morphology ( J:78008 )

• effects more severe in embryos than in adults

• sympathetic ganglia are generally smaller and aberrantly segmented

• reduced numbers of neurons in ganglia when targeting fails

abnormal superior cervical ganglion morphology ( J:78008 )

• shifted somewhat caudally in position ipsilateral to drooping eyelids

• caudal shift of ganglion is noticeable by E12.5

• levels of apoptosis are greater when position of the ganglion is severely shifted and axon targeting is disturbed

small superior cervical ganglion ( J:78008 )

• ipsilateral to drooping eyelids

abnormal sympathetic neuron morphology ( J:78008 )

• distribution and density of sympathetic fibers is abnormal

• abortive axonal growth

• no sympathetic outgrowth along the intercostals arteries at E13.5

• reduced outgrowth from prevertebral ganglia at E13.5

• failure to form fasciculated axonal bundles

• fail to innervate eyelid