Phenotypes associated with this allele

• Allele Symbol: Gfra3^tm1Jmi
• Allele Name: targeted mutation 1, Jeffrey Milbrandt
• Allele ID: MGI:2183558
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfra3^tm1Jmi/Gfra3^tm1Jmi	involves: 129X1/SvJ * FVB/N	MGI:2651768

Genotype
MGI:2651768

hm1

• Allelic Composition: Gfra3^tm1Jmi/Gfra3^tm1Jmi
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

blepharoptosis ( J:78008 )

• drooping eyelids seen in about 30% of adult mice

nervous system

abnormal sympathetic system morphology ( J:78008 )

• modestly reduced numbers of sympathetic precursors along the dorsal aorta at E10.5

abnormal sympathetic ganglion morphology ( J:78008 )

• sympathetic ganglia are generally smaller and aberrantly segmented

abnormal superior cervical ganglion morphology ( J:78008 )

• shifted somewhat caudally in position ipsilateral to drooping eyelids

small superior cervical ganglion ( J:78008 )

• ipsilateral to drooping eyelids

abnormal sympathetic neuron morphology ( J:78008 )

• distribution and density of sympathetic fibers is abnormal

• abortive axonal growth

• failure to form fasciculated axonal bundles fail to innervate eyelid