Phenotypes associated with this allele

• Allele Symbol: Ehmt2^tm1Yshk
• Allele Name: targeted mutation 1, Yoichi Shinkai
• Allele ID: MGI:2183571
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ehmt2^tm1Yshk/Ehmt2^tm1Yshk	B6.Cg-Ehmt2^tm1Yshk	MGI:3851732
hm2	Ehmt2^tm1Yshk/Ehmt2^tm1Yshk	involves: C57BL/6 * CBA	MGI:2656137

Genotype
MGI:3851732

hm1

• Allelic Composition: Ehmt2^tm1Yshk/Ehmt2^tm1Yshk
• Genetic Background: B6.Cg-Ehmt2^tm1Yshk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77998 )

• embryos die around E9.5-E12.5

embryo

embryonic growth arrest ( J:77998 )

• developmental arrest around E8; E9.5 embryos develop only to the 5-6 somite stage instead of to the wild-type 21-25 somite stage

cellular

abnormal cell physiology ( J:77998 )

• primary embryonic fibroblasts from E9 embryos show severe growth defects

abnormal apoptosis ( J:77998 )

• increase in apoptosis in E9.5 embryos

Genotype
MGI:2656137

hm2

• Allelic Composition: Ehmt2^tm1Yshk/Ehmt2^tm1Yshk
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77998 )

• embryos die around E9.5-E12.5

embryo

embryonic growth arrest ( J:77998 )

• E9.5 embryos develop only to the 5-6 somite stage, as opposed to the 21-25 somite stage