Phenotypes associated with this allele

• Allele Symbol: Agrp^tm1Sqn
• Allele Name: targeted mutation 1, Su Qian
• Allele ID: MGI:2183577
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agrp^tm1Sqn/Agrp^tm1Sqn	involves: 129S7/SvEvBrd	MGI:2654839
hm2	Agrp^tm1Sqn/Agrp^tm1Sqn	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3695566
cx3	Agrp^tm1Sqn/Agrp^tm1Sqn Npy^tm1Rpa/Npy^tm1Rpa	involves: 129S7/SvEvBrd	MGI:2654840

Genotype
MGI:2654839

hm1

• Allelic Composition: Agrp^tm1Sqn/Agrp^tm1Sqn
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:78034 )

• viable and fertile; no defects observed in locomotor activity, growth rates, body composition, or food intake; responses to starvaton, diet-induced obesity, and administration of leptin and neuropeptide Y were similar to controls

Genotype
MGI:3695566

hm2

• Allelic Composition: Agrp^tm1Sqn/Agrp^tm1Sqn
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

mortality/aging

extended life span ( J:116654 )

• median survival of mutants (101 weeks) exceeds wild-type (92 weeks) by 9.8% when consuming a high fat diet from 7.7 months onward

• hazard ratio of mutants relative to wild-type (0.494) indicates mutants show ~2-fold reduction in mortality incidence, even on high fat diet from 7.7 months of age onward

growth/size/body

decreased lean body mass ( J:116654 )

♀ • female mutants exhibit a leaner phenotype than wild-type, statistically significant between 12 to 30 weeks on a low fat diet

increased body weight ( J:116654 )

♂ • male mutants tend to weigh more than wild-type from 35 weeks onward, although difference is not always significant

homeostasis/metabolism

impaired adaptive thermogenesis ( J:116654 )

♀ • females show an apparent cold sensitivity when placed at 4 degrees, but after 4 hours, they recover to match wild-type littermates

abnormal energy expenditure ( J:116654 )

♀ • female mutants show a trend (but not significant) toward higher energy expenditure compared to littermates

behavior/neurological

increased food intake ( J:116654 )

♀ • female mutants show a trend (but not significant) toward higher food intake compared to littermates

Genotype
MGI:2654840

cx3

• Allelic Composition: Agrp^tm1Sqn/Agrp^tm1Sqn; Npy^tm1Rpa/Npy^tm1Rpa
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:78034 )

• mice exhibit no obvious deficiency in body weight or feeding behavior and respond to starvation in a similar manner to controls