Phenotypes associated with this allele

• Allele Symbol: Mc3r^tm1Cone
• Allele Name: targeted mutation 1, Roger D Cone
• Allele ID: MGI:2183579
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mc3r^tm1Cone/Mc3r^tm1Cone	B6.129S4-Mc3r^tm1Cone	MGI:3639353
hm2	Mc3r^tm1Cone/Mc3r^tm1Cone	involves: 129S4/SvJae * C57BL/6J	MGI:3639354
ht3	Mc3r^tm1Cone/Mc3r^+	involves: 129S4/SvJae * C57BL/6J	MGI:3639355

Genotype
MGI:3639353

hm1

• Allelic Composition: Mc3r^tm1Cone/Mc3r^tm1Cone
• Genetic Background: B6.129S4-Mc3r^tm1Cone

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased compensatory feeding amount ( J:109494 )

• after a 16-hour fast, i.p. injection of CCK-8 into females produces a 50% inhibition of food intake in the first 30 minutes in mutants and wild-type and intake continued to be inhibited for up to 180 minutes

Genotype
MGI:3639354

hm2

• Allelic Composition: Mc3r^tm1Cone/Mc3r^tm1Cone
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

growth/size/body

increased body weight ( J:78132 )

• female null mice are significantly heavier than wild-type around 50-60 days of age

obese ( J:78132 )

• mutants are obese with the proportion of fat increasing by ~40% around 15-20 weeks of age compared to wild-type (31.8% in wild-type vs 45.2% in Mc3r-null mice)

homeostasis/metabolism

abnormal respiratory quotient ( J:78132 )

• mice show a trend toward greater oxygen consumption on low or high fat diets compared to wild-type

• when switched to high fat chow, mutants show a dramatic increase in respiratory quotient 24 hours after the switch

• mutants show a reduced RQ compared to wild-type on a low fat chow diet and a higher RQ on high fat chow

behavior/neurological

abnormal food intake ( J:78132 )

• despite increased body fat, mice do not exhibit weight gain or increased food consumption

adipose tissue

increased total body fat amount ( J:78132 )

• on a low-fat chow, mutants show increased fat content without gross weight being different

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:78132

Genotype
MGI:3639355

ht3

• Allelic Composition: Mc3r^tm1Cone/Mc3r⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

growth/size/body

obese ( J:78132 )

• heterozygous mice show an intermediate increase in percentage of body fat compared to wild-type (31.8%) and null mice (45.8%) around 15-20 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:78132