Phenotypes associated with this allele

• Allele Symbol: Mc3r^tm1Lvp
• Allele Name: targeted mutation 1, Lex H T Van der Ploeg
• Allele ID: MGI:2183582
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mc3r^tm1Lvp/Mc3r^tm1Lvp	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3850835
cx2	Mc3r^tm1Lvp/Mc3r^tm1Lvp Mc4r^tm1Dhu/Mc4r^tm1Dhu	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3850836

Genotype
MGI:3850835

hm1

• Allelic Composition: Mc3r^tm1Lvp/Mc3r^tm1Lvp
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:64365 )

• at 6 months, fat mass is twice as much as in wild-type mice

• by 6 months, all fat depots, with the exception of female mesenteric depot, are heavier than in wild-type mice

abnormal brown fat cell morphology ( J:64365 )

• the number of large unilocular cells is increased in brown adipose tissue compared to in wild-type mice

decreased brown fat cell number ( J:64365 )

increased white fat cell size ( J:64365 )

behavior/neurological

abnormal eating behavior ( J:64365 )

• when fed regular chow, male mice exhibit hypophagia and increased feed efficiency compared with wild-type mice

• female mice exhibit increased feed efficiency compared with wild-type mice

• however, mice fed a high fat diet exhibit normal food consumption and mice exhibit normal anorectic actions of MTII (a non-selective melacortin agonist

abnormal motor capabilities/coordination/movement ( J:64365 )

• at 5 to 6 months, female mice exhibit reduction in fine movements compared with wild-type mice

decreased locomotor activity ( J:64365 )

• in female mice at 5 to 6 months

growth/size/body

decreased lean body mass ( J:64365 )

• at 6 months, lean mass is reduced 15% to 20% compared to in wild-type mice

increased body weight ( J:64365 )

• slight at 26 weeks in male mice

decreased body length ( J:64365 )

• in young female mice

increased susceptibility to diet-induced obesity ( J:64365 )

• in female mice

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:64365 )

• in female mice

increased circulating insulin level ( J:64365 )

• at 6 months in male mice

increased circulating leptin level ( J:64365 )

• at 6 months

limbs/digits/tail

short femur ( J:64365 )

• in 15 to 17 and 26 to 27 week old females

skeleton

short femur ( J:64365 )

• in 15 to 17 and 26 to 27 week old females

Genotype
MGI:3850836

cx2

• Allelic Composition: Mc3r^tm1Lvp/Mc3r^tm1Lvp; Mc4r^tm1Dhu/Mc4r^tm1Dhu
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

growth/size/body

increased body weight ( J:64365 )

• at 26 weeks, female mice are 27% heavier than Mc4r^tm1Dhu homozygotes

• at 26 weeks, male mice are 13% heavier than Mc4r^tm1Dhu homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:64365