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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk9tm1Mka
targeted mutation 1, Michael Karin
MGI:2183601
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk9tm1Mka/Mapk9tm1Mka B6.129-Mapk9tm1Mka MGI:3619034
hm2
 		Mapk9tm1Mka/Mapk9tm1Mka either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:3619035
hm3
 		Mapk9tm1Mka/Mapk9tm1Mka either: (involves: 129S2/SvPas) or (involves: 129S1/Sv * 129X1/SvJ) MGI:3619033
hm4
 		Mapk9tm1Mka/Mapk9tm1Mka involves: 129/Sv * C57BL/6 MGI:3851982
cn5
 		Krastm4Tyj/Kras+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4948963
cx6
 		Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129 MGI:3619039
cx7
 		Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+ 		involves: 129 MGI:3619037
cx8
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+ 		involves: 129 MGI:3619038
cx9
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129 * C57BL/6 MGI:3619040
cx10
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+ 		involves: 129 * C57BL/6 MGI:3619041
cx11
 		Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129 * C57BL/6 MGI:3619042
cx12
 		Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 MGI:6384032
cx13
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+ 		involves: 129/Sv * 129P2/OlaHsd MGI:4948961


Genotype
MGI:3619034
hm1
Allelic
Composition		 Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 B6.129-Mapk9tm1Mka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:80452 )
N
• on a high fat high calorie diet homozygotes become obese and display increased circulating glucose and insulin similar to wild-type mice and unlike Mapk8tm1Wag homozygotes
abnormal physiological response to xenobiotic ( J:103476 )
• induction of CYP1A1 by TCDD is significantly reduced in the thymus and testis but not in the liver, while induction of CYP1B1 by TCDD is increased in the liver but unchanged in the thymus




Genotype
MGI:3619035
hm2
Allelic
Composition		 Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic potential ( J:105153 )
• at 1 month of age in the CA1 region, field excitatory postsynaptic potentials are reduced particularly at higher stimulus intensities
reduced long-term potentiation ( J:105153 )
• at 1 month of age, reduced amplitude of long term potentiation in the CA1 and CA3 regions is seen after application of high frequency stimulation; however in the CA3 region post-tetanus potentiation and paired pulse facilitation are similar to wild-type
decreased post-tetanic potentiation ( J:105153 )
• at 1 month of age in the CA1 region but bot in the CA3 region
abnormal neurotransmitter secretion ( J:105153 )
• at 1 month of age in the CA1 region, the pool of docked vesicles appears to be smaller than in wild-type mice
decreased paired-pulse facilitation ( J:105153 )
• at 1 month of age in the CA1 region, paired-pulse facilitation is reduced over a wide range of interpulse intervals especially at shorter intervals
• paired pulse facilitation is not decreased in the CA3 region




Genotype
MGI:3619033
hm3
Allelic
Composition		 Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 either: (involves: 129S2/SvPas) or (involves: 129S1/Sv * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78129 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
abnormal T cell activation ( J:78129 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 36 hours of culture with anti-CD3 antibody homozygous T cells produce very little IL2, IL4 or IFNG unlike wild-type cells
decreased T cell proliferation ( J:78129 )
• reduced proliferation of splenic T cells after stimulation with anti-CD3 antibody with or without anti-CD28 antibody, especially at lower concentrations of antibodies
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells

hematopoietic system
decreased T cell apoptosis ( J:78129 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
abnormal T cell activation ( J:78129 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 36 hours of culture with anti-CD3 antibody homozygous T cells produce very little IL2, IL4 or IFNG unlike wild-type cells
decreased T cell proliferation ( J:78129 )
• reduced proliferation of splenic T cells after stimulation with anti-CD3 antibody with or without anti-CD28 antibody, especially at lower concentrations of antibodies
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells

cellular
decreased T cell apoptosis ( J:78129 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
decreased T cell proliferation ( J:78129 )
• reduced proliferation of splenic T cells after stimulation with anti-CD3 antibody with or without anti-CD28 antibody, especially at lower concentrations of antibodies
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells




Genotype
MGI:3851982
hm4
Allelic
Composition		 Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardium layer morphology ( J:102152 )
• after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA)

muscle
abnormal myocardium layer morphology ( J:102152 )
• after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA)
decreased cardiomyocyte apoptosis ( J:102152 )
• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type

cellular
decreased cardiomyocyte apoptosis ( J:102152 )
• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type




Genotype
MGI:4948963
cn5
Allelic
Composition		 Krastm4Tyj/Kras+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:170904 )
• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

respiratory system
increased lung tumor incidence ( J:170904 )
• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice




Genotype
MGI:3619039
cx6
Allelic
Composition		 Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote




Genotype
MGI:3619037
cx7
Allelic
Composition		 Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote




Genotype
MGI:3619038
cx8
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote




Genotype
MGI:3619040
cx9
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
decreased hindbrain apoptosis ( J:58622 )
• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
increased forebrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
increased hindbrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
incomplete rostral neuropore closure ( J:58622 )
• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused
abnormal forebrain development ( J:58622 )
• the lumen of the forebrain vesicles is incompletely formed

growth/size/body
embryonic growth retardation ( J:58622 )

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:103476 )
• double homozygous MEFs display little or no CYP1A1 induction following TCDD treatment

embryo
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
incomplete rostral neuropore closure ( J:58622 )
• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused

cellular
decreased hindbrain apoptosis ( J:58622 )
• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
increased forebrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
increased hindbrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells




Genotype
MGI:3619041
cx10
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:58622 )
• fewer than expected mice are found at weaning; however expected numbers are found at E12.5 to E15.5

nervous system
incomplete rostral neuropore closure ( J:58622 )
• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice
abnormal brain development ( J:58622 )
• at E15.5 in exencephalic mice, the brain tissue is expanded upward
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
absent brain ventricles ( J:58622 )
• at E12.5, in exencephalic mice the cerebral ventricles are absent
abnormal diencephalon morphology ( J:58622 )
• at E15.5 in exencephalic mice, the diencephalon is enlarged
abnormal cerebral hemisphere morphology ( J:58622 )
• at E15.5 in exencephalic mice, the cerebral hemispheres are displaced laterally
exencephaly ( J:58622 )
• some embryos display exencephaly with absence of the entire creanial roof at E12.5

embryo
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
incomplete rostral neuropore closure ( J:58622 )
• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice




Genotype
MGI:3619042
cx11
Allelic
Composition		 Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:58622 )
N
• no mice display exencephaly and no indications of increased mortality are seen




Genotype
MGI:6384032
cx12
Allelic
Composition		 Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
early eyelid opening ( J:176244 )
• eyes are open at birth
• however, mice exhibit normal retinal morphology




Genotype
MGI:4948961
cx13
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eyelid morphology ( J:170904 )
• mice exhibit an eyelid closure defect compared with wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory