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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gna12tm1Citb
targeted mutation 1, California Institute of Technology - Biology
MGI:2183606
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gna12tm1Citb/Gna12tm1Citb involves: 129S1/Sv * C57BL/6 MGI:3037545
cn2
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm2Cgh/Gna13tm2Cgh
Grhl3tm1(cre)Cgh/Grhl3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL MGI:4438090
cn3
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Tek-icre/ERT2)1Soff/? 		involves: 129P2/OlaHsd * 129S1/Sv * FVB/N MGI:3837460
cn4
 		Cd19tm1(cre)Cgn/Cd19+
Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N MGI:3699320
cn5
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Lck-cre)548Jxm/0 		involves: 129S1/Sv * C57BL/6 * CBA MGI:3849203
cn6
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Mx1-cre)1Cgn/0 		involves: 129S1/Sv * C57BL/6 * CBA * FVB/N MGI:3699352
cn7
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
X/Tg(Myh11-icre/ERT2)1Soff 		involves: 129S1/Sv * FVB/N MGI:3819345
cx8
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13tm1Soff 		involves: 129S1/Sv * C57BL/6 MGI:3037546
cx9
 		Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13+ 		involves: 129S1/Sv * C57BL/6 MGI:3037547
cx10
 		Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13+ 		involves: 129S1/Sv * C57BL/6 MGI:3037548
cx11
 		Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13tm1Soff 		involves: 129S1/Sv * C57BL/6 MGI:3037549
cx12
 		Gna12tm1Citb/Gna12tm1Citb
Gnaqtm1Soff/Gnaqtm1Soff 		involves: 129S1/Sv * C57BL/6 MGI:3037550
cx13
 		Gna12tm1Citb/Gna12+
Gnaqtm1Soff/Gnaqtm1Soff 		involves: 129S1/Sv * C57BL/6 MGI:3037551


Genotype
MGI:3037545
hm1
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:77728 )
• mice are viable and fertile; no gross morphological or behavioral abnormalities




Genotype
MGI:4438090
cn2
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2Cgh/Gna13tm2Cgh
Grhl3tm1(cre)Cgh/Grhl3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:157446 )
• mutants die by 10.5 days post coitus (dpc)

embryo
abnormal embryo development ( J:157446 )
• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc
abnormal embryo turning ( J:157446 )
• embryos show turning defects




Genotype
MGI:3837460
cn3
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Tek-icre/ERT2)1Soff/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:146132 )
N
• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock




Genotype
MGI:3699320
cn4
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased marginal zone B cell number ( J:117663 )
• marginal zone B cell numbers are strongly reduced compared to controls
abnormal B cell physiology ( J:117663 )
• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells

immune system
decreased marginal zone B cell number ( J:117663 )
• marginal zone B cell numbers are strongly reduced compared to controls
abnormal B cell physiology ( J:117663 )
• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells




Genotype
MGI:3849203
cn5
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:149560 )
• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
thymus hyperplasia ( J:149560 )
• thymus weight and cellularity is increased by about a third
increased CD4-positive, alpha-beta T cell number ( J:149560 )
• CD4+ T cell numbers in the lymph nodes and blood are increased by about a third
increased CD8-positive, alpha-beta T cell number ( J:149560 )
• CD8+ T cell numbers in the lymph nodes are slightly increased
abnormal CD4-positive, alpha-beta T cell physiology ( J:149560 )
• CD4+ T cells have longer interactions between themselves and with allogenic dendritic cells
• CD4+ T cells have a higher affinity for ICAM-coated surfaces
• CD4+ T cells have decreased motility through transwell filters
• CD4+ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes
lymph node hyperplasia ( J:149560 )
• axillary, cervical, inguinal and mesenteric lymph nodes are increased in weight and cell number by about a third
increased susceptibility to type IV hypersensitivity reaction ( J:149560 )
• an increase in ear thickness is observed after sensitization and challenge with DNFB
• CD4+ T cells in cervical lymph nodes have a higher proliferation rate than those of control mice after DNFB challenge
increased interleukin-2 secretion ( J:149560 )
• IL-2 secretion is enhanced by CD4+ T cells in response to allogenic stimulation
increased susceptibility to autoimmune diabetes ( J:149560 )
• diabetes development is accelerated and aggravated after streptozotocin induction with high glucose levels detected
• peripancreatic lymph nodes are enlarged 5-6 days after disease induction
• increased numbers of CD4+ T cells are noted in the pancreas 14 days after disease induction compared to controls

hematopoietic system
increased T cell proliferation ( J:149560 )
• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
thymus hyperplasia ( J:149560 )
• thymus weight and cellularity is increased by about a third
increased CD4-positive, alpha-beta T cell number ( J:149560 )
• CD4+ T cell numbers in the lymph nodes and blood are increased by about a third
increased CD8-positive, alpha-beta T cell number ( J:149560 )
• CD8+ T cell numbers in the lymph nodes are slightly increased
abnormal CD4-positive, alpha-beta T cell physiology ( J:149560 )
• CD4+ T cells have longer interactions between themselves and with allogenic dendritic cells
• CD4+ T cells have a higher affinity for ICAM-coated surfaces
• CD4+ T cells have decreased motility through transwell filters
• CD4+ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes

endocrine/exocrine glands
thymus hyperplasia ( J:149560 )
• thymus weight and cellularity is increased by about a third

cellular
increased T cell proliferation ( J:149560 )
• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased




Genotype
MGI:3699352
cn6
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:99597 )
• platelet thrombus formation is severely impaired ex vivo after treatment of platelets with polyinosinic-polycytidylic acid (PIPC) to induce recombination
• however, initial adhesion of platelets is similar to wild-type
abnormal platelet physiology ( J:99597 )
• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
decreased platelet aggregation ( J:99597 )
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
increased bleeding time ( J:99597 )
• very large increase in bleeding time in interferon-responsive tissues
• when bone marrow-derived cells PIPC-treated mice are transplanted into irradiated wild-type mice, 4 weeks later mice have greatly prolonged bleeding times (>20 minutes) compared with mice receiving cells from noninduced controls

hematopoietic system
abnormal platelet physiology ( J:99597 )
• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
decreased platelet aggregation ( J:99597 )
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations




Genotype
MGI:3819345
cn7
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
X/Tg(Myh11-icre/ERT2)1Soff
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased systemic arterial blood pressure ( J:141641 )
• tamoxifen-treated mice exhibit decreased blood pressure following treatment with U46619, vasopressin and endothelin compared to in wild-type mice
• tamoxifen-treated mice exposed to DOCA-salt do not develop hypertension and DOCA-salt treated mice exposed to tamoxifen following the onset of hypertension exhibit a drop in blood pressure compared to in similarly treated wild-type mice
decreased vasoconstriction ( J:141641 )
• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice

muscle
decreased vasoconstriction ( J:141641 )
• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice




Genotype
MGI:3037546
cx8
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13tm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:77728 )
• resorbed by E9.5 with severe necrosis

embryo
embryonic growth arrest ( J:77728 )
• arrest by E8.25




Genotype
MGI:3037547
cx9
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm1Soff/Gna13+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3037548
cx10
Allelic
Composition		 Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:77728 )
• mice are viable and fertile




Genotype
MGI:3037549
cx11
Allelic
Composition		 Gna12tm1Citb/Gna12+
Gna13tm1Soff/Gna13tm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm1Soff mutation (0 available); any Gna13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:77728 )
• growth arrest at E8.5




Genotype
MGI:3037550
cx12
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gnaqtm1Soff/Gnaqtm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:77728 )
• mutant embryos appear normal until E12, then development appears to stop; embryos begin resorbtion at E13.5




Genotype
MGI:3037551
cx13
Allelic
Composition		 Gna12tm1Citb/Gna12+
Gnaqtm1Soff/Gnaqtm1Soff
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:77728 )
• fewer than expected homozygotes were present at P30




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory