Phenotypes associated with this allele

• Allele Symbol: Icmt^tm1Hzo
• Allele Name: targeted mutation 1, Huda Y Zoghbi
• Allele ID: MGI:2183607
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icmt^tm1Hzo/Icmt^tm1Hzo	involves: 129S/SvEv	MGI:2668376

Genotype
MGI:2668376

hm1

• Allelic Composition: Icmt^tm1Hzo/Icmt^tm1Hzo
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77742 )

• normal ratios of homozygotes at E10.5 but not later

• no homozygous embryos after E12.5

nervous system

increased forebrain apoptosis ( J:77742 )

• high levels of apoptosis at E10.5, particularly in the neural tube and forebrain region

increased neural tube apoptosis ( J:77742 )

• high levels of apoptosis at E10.5, particularly in the neural tube and forebrain region

growth/size/body

decreased embryo size ( J:77742 )

• embryos at E10.5 are smaller than littermate controls

hematopoietic system

abnormal definitive hematopoiesis ( J:77742 )

• no red blood cells in the liver bud region at E10.5

liver/biliary system

abnormal liver development ( J:77742 )

abnormal liver bud morphology ( J:77742 )

• ventral foregut endoderm cells fail to migrate into the septum transversum

• thickening of the ventral foregut endoderm does occur

delayed hepatic development ( J:77742 )

• albumin gene expression is delayed

absent liver ( J:77742 )

• liver agenesis; no hepatic structures at E10.5

embryo

decreased embryo size ( J:77742 )

• embryos at E10.5 are smaller than littermate controls

integument

pallor ( J:77742 )

• small embryos appear pale and anemic

cellular

increased forebrain apoptosis ( J:77742 )

• high levels of apoptosis at E10.5, particularly in the neural tube and forebrain region

increased neural tube apoptosis ( J:77742 )

• high levels of apoptosis at E10.5, particularly in the neural tube and forebrain region