Phenotypes associated with this allele

• Allele Symbol: Wt1^tm1Asc
• Allele Name: targeted mutation 1, Andreas Schedl
• Allele ID: MGI:2183640
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wt1^tm1Asc/Wt1^tm1Asc	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3044972
ht2	Wt1^tm1Asc/Wt1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3044970

Genotype
MGI:3044972

hm1

• Allelic Composition: Wt1^tm1Asc/Wt1^tm1Asc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:71149 )

• death within 24 hrs after birth due to kidney defects

renal/urinary system

abnormal renal glomerulus morphology ( J:71149 )

• increase in stromal component and decrease in nephrogenic zone and number of glomerular generations

small kidney ( J:71149 )

• characterized by localized macroscopic hemorrhage

reproductive system

decreased germ cell number ( J:71149 )

• germ cells are fewer and abnormally organized

primary sex reversal ( J:71149 )

• gonads of XY mice are ovarian-like and cryptorchid

cellular

decreased germ cell number ( J:71149 )

• germ cells are fewer and abnormally organized

Genotype
MGI:3044970

ht2

• Allelic Composition: Wt1^tm1Asc/Wt1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:71149 )

• death due to kidney defects within 24 hrs after birth

renal/urinary system

abnormal renal glomerulus morphology ( J:71149 )

• increase in stromal tissue and decrease in tubular epithelium

small kidney ( J:71149 )

• characterized by localized macroscopic hemorrhage

reproductive system

decreased germ cell number ( J:71149 )

• germ cells are fewer and abnormally organized

primary sex reversal ( J:71149 )

• gonads of XY mice are ovarian-like and cryptorchid

cellular

decreased germ cell number ( J:71149 )

• germ cells are fewer and abnormally organized