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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctbp1tm1Sor
targeted mutation 1, Philippe Soriano
MGI:2183644
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctbp1tm1Sor/Ctbp1tm1Sor involves: 129S4/SvJaeSor * C57BL/6 MGI:3696580
cx2
 		Ctbp1tm1Sor/Ctbp1+
Ctbp2Gt(ROSA61)Sor/Ctbp2+ 		involves: 129S4/SvJaeSor MGI:3696582
cx3
 		Ctbp1tm1Sor/Ctbp1tm1Sor
Ctbp2Gt(ROSA61)Sor/Ctbp2+ 		involves: 129S4/SvJaeSor MGI:3696583
cx4
 		Ctbp1tm1Sor/Ctbp1+
Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor 		involves: 129S4/SvJaeSor MGI:3696584
cx5
 		Ctbp1tm1Sor/Ctbp1tm1Sor
Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor 		involves: 129S4/SvJaeSor MGI:3696585


Genotype
MGI:3696580
hm1
Allelic
Composition		 Ctbp1tm1Sor/Ctbp1tm1Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp1tm1Sor mutation (1 available); any Ctbp1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:77905 )
• about 23% of homozygotes die before 20 days of age
• survivors are fertile

growth/size/body
decreased body size ( J:77905 )
• 30% smaller than wild-type controls




Genotype
MGI:3696582
cx2
Allelic
Composition		 Ctbp1tm1Sor/Ctbp1+
Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp1tm1Sor mutation (1 available); any Ctbp1 mutation (35 available)
Ctbp2Gt(ROSA61)Sor mutation (1 available); any Ctbp2 mutation (574 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:77905 )
• about 26% of homozygotes die before 20 days of age

growth/size/body
decreased body size ( J:77905 )
• smaller than wild-type controls




Genotype
MGI:3696583
cx3
Allelic
Composition		 Ctbp1tm1Sor/Ctbp1tm1Sor
Ctbp2Gt(ROSA61)Sor/Ctbp2+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp1tm1Sor mutation (1 available); any Ctbp1 mutation (35 available)
Ctbp2Gt(ROSA61)Sor mutation (1 available); any Ctbp2 mutation (574 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
decreased embryo size ( J:77905 )
• embryos small

cardiovascular system
hemorrhage ( J:77905 )
• extensive hemorrhage in embryos

skeleton

muscle
abnormal diaphragm morphology ( J:77905 )
• lacks myofibers

embryo
decreased embryo size ( J:77905 )
• embryos small




Genotype
MGI:3696584
cx4
Allelic
Composition		 Ctbp1tm1Sor/Ctbp1+
Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp1tm1Sor mutation (1 available); any Ctbp1 mutation (35 available)
Ctbp2Gt(ROSA61)Sor mutation (1 available); any Ctbp2 mutation (574 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube closure ( J:77905 )
• incomplete closure

embryo
incomplete embryo turning ( J:77905 )
• development arrested at the turning stage
abnormal neural tube closure ( J:77905 )
• incomplete closure




Genotype
MGI:3696585
cx5
Allelic
Composition		 Ctbp1tm1Sor/Ctbp1tm1Sor
Ctbp2Gt(ROSA61)Sor/Ctbp2Gt(ROSA61)Sor
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp1tm1Sor mutation (1 available); any Ctbp1 mutation (35 available)
Ctbp2Gt(ROSA61)Sor mutation (1 available); any Ctbp2 mutation (574 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryonic growth arrest ( J:77905 )
• arrested at the headfold stage
abnormal embryonic neuroepithelium morphology ( J:77905 )
• blebs or blisters form on the neuroectoderm
decreased somite size ( J:77905 )
• small somites
abnormal allantois morphology ( J:77905 )
• sometimes misshapen

cardiovascular system
abnormal heart development ( J:77905 )
• little heart morphogenesis

nervous system
abnormal embryonic neuroepithelium morphology ( J:77905 )
• blebs or blisters form on the neuroectoderm




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory