About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(APPV717I)1130Kha
transgene insertion 1130, Karen Hsiao Ashe
MGI:2183645
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Tg(APPV717I)1130Kha/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3722316
cx2
 		Apoetm1Unc/Apoe+
Tg(APPV717I)1130Kha/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3722317
cx3
 		Tg(APPV717I)1130Kha/0
Tg(SOD1)76Dpr/0 		involves: C3H/HeJ * C57BL/6J * FVB/N MGI:3722319
cx4
 		Tg(APPV717I)1130Kha/0
Tg(Pgk1-FGF2)15Cofn/0 		involves: FVB/N MGI:3722322
tg5
 		Tg(APPV717I)1130Kha/0 (C57BL/6 x FVB/N)F1 MGI:3722305
tg6
 		Tg(APPV717I)1130Kha/0 (CAST/Ei x FVB/N)F1 MGI:3722303
tg7
 		Tg(APPV717I)1130Kha/0 (DBA/2 X FVB/N)F1 MGI:3722304
tg8
 		Tg(APPV717I)1130Kha/0 FVB/N-Tg(APPV717I)1130Kha MGI:3722299
tg9
 		Tg(APPV717I)1130Kha/0 involves: C3H/HeJ * C57BL/6J * FVB/N MGI:3722318
tg10
 		Tg(APPV717I)1130Kha/0 involves: FVB/N MGI:2684654
tg11
 		Tg(APPV717I)1130Kha/? involves: CAST/Ei * FVB/N MGI:3722315


Genotype
MGI:3722316
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(APPV717I)1130Kha/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(APPV717I)1130Kha mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• absence of Apoe does not modify or improve mouse survival relative to Tg(APPV717I)1130Kha mice expressing Apoe; significant mortality before 150 days of age is observed




Genotype
MGI:3722317
cx2
Allelic
Composition		 Apoetm1Unc/Apoe+
Tg(APPV717I)1130Kha/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(APPV717I)1130Kha mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• absence of Apoe does not modify or improve mouse survival relative to Tg(APPV717I)1130Kha mice expressing Apoe; significant mortality before 150 days of age is observed




Genotype
MGI:3722319
cx3
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Tg(SOD1)76Dpr/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• 1/7 animals died prior to 170 days




Genotype
MGI:3722322
cx4
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Tg(Pgk1-FGF2)15Cofn/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• mice die sooner than Tg(APPV717I)1130Kha single transgenics




Genotype
MGI:3722305
tg5
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Genetic
Background		 (C57BL/6 x FVB/N)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• Background Sensitivity: mice die at least as early as mice on FVB/N inbred background




Genotype
MGI:3722303
tg6
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Genetic
Background		 (CAST/Ei x FVB/N)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:43446 )
N
• Background Sensitivity: all mice remained alive for up to 407 days




Genotype
MGI:3722304
tg7
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Genetic
Background		 (DBA/2 X FVB/N)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• Background Sensitivity: mice die at least as early as mice on FVB/N inbred background




Genotype
MGI:3722299
tg8
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Genetic
Background		 FVB/N-Tg(APPV717I)1130Kha
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• Background Sensitivity: 100% of mice die prematurely, most by 150 days of age; lethality begins to be observed at ~55 days




Genotype
MGI:3722318
tg9
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• Background Sensitivity: only 70% of mic die prematurely, compared to 100% of FVB/N-Tg(APPV717I)1130Kha mice




Genotype
MGI:2684654
tg10
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:29880 )
• 50% dead at 87 days of age

behavior/neurological
abnormal fear/anxiety-related behavior ( J:29880 )
• 84% neophobic at 100 days of age

reproductive system
reduced fertility ( J:29880 )
• poor breeders

nervous system
abnormal astrocyte morphology ( J:29880 )
• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex




Genotype
MGI:3722315
tg11
Allelic
Composition		 Tg(APPV717I)1130Kha/?
Genetic
Background		 involves: CAST/Ei * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• Background Sensitivity: 38% of (CAST x FVB/N)F2 mice and 26% of (CAST x FVB/N)F1 x FVB/N mice die before 150 days of age, whereas no (CAST x FVB/N)F1 mice die prematurely




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory