|
Allele Symbol Allele Name Allele ID |
Tg(APP)6209Kha transgene insertion 6209, Karen Hsiao Ashe MGI:2183649 |
||||||||||||||||||||||||||||
| Summary |
6 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• essentially all mice die by 80 days of age, compared to ~50% of Tg(APP)6209Kha single transgenics by 150 days
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: 8/17 mice die before 150 days of age (mean age ~95 days)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: mice do not exhibit premature death
|
|
• levels are not significantly different from that observed on other backgrounds
|
|
• levels are not significantly different from that observed on other backgrounds
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: 24/52 mice die before 150 days of age (mean age ~99 days)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 50% dead at 156 days of age
(J:29880)
• Background Sensitivity: ~50% of mice die by 150 days of age; lethality begins to be observed at ~55 days
(J:43446)
|
|
• levels are not significantly different from that observed on other backgrounds
|
|
• hypertrophic astrocytes in the parahippocampal area, hippocampus, amygdala, and cerebral cortex
|
|
• levels are not significantly different from that observed on other backgrounds
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 06/12/2024 MGI 6.13 |
|
|
|
||
Analysis Tools