Phenotypes associated with this allele

• Allele Symbol: Sp4^tm1Sus
• Allele Name: targeted mutation 1, Guntram Suske
• Allele ID: MGI:2183651
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp4^tm1Sus/Sp4^tm1Sus	involves: 129P2/OlaHsd * C57BL/6	MGI:2449974

Genotype
MGI:2449974

hm1

• Allelic Composition: Sp4^tm1Sus/Sp4^tm1Sus
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:77894 )

• approximately half the animals die within 10 days after birth

endocrine/exocrine glands

thymus hypoplasia ( J:77894 )

small testis ( J:77894 )

♂ • complete spermatogenesis detected in males despite small size

growth/size/body

postnatal growth retardation ( J:77894 )

• weight gain arrested within first 4 weeks of life

hematopoietic system

hematopoietic system phenotype ( J:77894 )

N • normal parameters for red cells, white cells, and platelets

thymus hypoplasia ( J:77894 )

spleen hypoplasia ( J:77894 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:77894 )

N • normal levels of alkaline phosphatase, albumin, creatinin, bilirubin, and urea

N • aspartate aminotransferase and lactate dehydrogenase 1 slightly elevated (20% increase) but not by significant amount

immune system

thymus hypoplasia ( J:77894 )

spleen hypoplasia ( J:77894 )

reproductive system

small testis ( J:77894 )

♂ • complete spermatogenesis detected in males despite small size

small uterus ( J:77894 )

♀ • reduced uterus size in females

delayed vaginal opening ( J:77894 )

• delayed vaginal opening time in females

reduced female fertility ( J:77894 )

♀ • sporadic success when bred with wild-type males

male infertility ( J:77894 )

♂ • complete male infertility when bred with wild-type females