Phenotypes associated with this allele

• Allele Symbol: Cyct^tm1Jlm
• Allele Name: targeted mutation 1, Jose Luis Millan
• Allele ID: MGI:2183657
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyct^tm1Jlm/Cyct^tm1Jlm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3040406

Genotype
MGI:3040406

hm1

• Allelic Composition: Cyct^tm1Jlm/Cyct^tm1Jlm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oligozoospermia ( J:77908 )

♂ • reduced number of spermatocytes, spermatids and spermatozoa in older (4-10 month old mice); apoptotic spermatocytes were observed

abnormal sperm motility ( J:77908 )

♂

abnormal oxidative phosphorylation ( J:77908 )

• the early onset of testicular atrophy appears to mimic a dysfunction of oxidative phosphorylation that normally occurs with aging

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:77908 )

♂ • abnormal basophilic structures near the luminal region of the seminiferous tubules by 6 weeks of age; in control animals, these structures were not apparent until 17 months of age

small testis ( J:77908 )

♂ • a number of testes from homozygous animals were small in size and low in weight

testicular atrophy ( J:77908 )

♂ • after 4 months of age, testes appeared atrophic, and lost germ cells as a result of increased apoptosis

reproductive system

oligozoospermia ( J:77908 )

♂ • reduced number of spermatocytes, spermatids and spermatozoa in older (4-10 month old mice); apoptotic spermatocytes were observed

abnormal sperm motility ( J:77908 )

♂

abnormal seminiferous tubule morphology ( J:77908 )

♂ • abnormal basophilic structures near the luminal region of the seminiferous tubules by 6 weeks of age; in control animals, these structures were not apparent until 17 months of age

small testis ( J:77908 )

♂ • a number of testes from homozygous animals were small in size and low in weight

testicular atrophy ( J:77908 )

♂ • after 4 months of age, testes appeared atrophic, and lost germ cells as a result of increased apoptosis

impaired fertilization ( J:77908 )

• reduced ability of sperm to fertilize oocytes