Phenotypes associated with this allele

• Allele Symbol: Rxrg^tm1Ysa
• Allele Name: targeted mutation 1, Yumiko Saga
• Allele ID: MGI:2183715
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rxrg^tm1Ysa/Rxrg^tm1Ysa	B6.129S2-Rxrg^tm1Ysa	MGI:3844302
hm2	Rxrg^tm1Ysa/Rxrg^tm1Ysa	either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * ICR)	MGI:3844301

Genotype
MGI:3844302

hm1

• Allelic Composition: Rxrg^tm1Ysa/Rxrg^tm1Ysa
• Genetic Background: B6.129S2-Rxrg^tm1Ysa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

increased muscle relaxation ( J:77613 )

• Background Sensitivity: respond to chlorpromazine with severe muscle relaxation rather than catalepsy

Genotype
MGI:3844301

hm2

• Allelic Composition: Rxrg^tm1Ysa/Rxrg^tm1Ysa
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * ICR)

mortality/aging

premature death ( J:77613 )

• Background Sensitivity: many die at 1-2 months of age when the 129 contribution to the genetic background is about 50%

• Background Sensitivity: normal survival when genetic background contains less than 25% 129

nervous system

abnormal striatum morphology ( J:77613 )

• 25% reduction of neurons

behavior/neurological

catalepsy ( J:77613 )

• Background Sensitivity: duration of catalepsy induced by the dopamine antagonist chlorpromazine is significantly reduced