Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crabp1tm1Ipc mutation
(0 available);
any
Crabp1 mutation
(18 available)
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normal phenotype
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• embryos and adults appeared grossly normal; animals are viable and fertile
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crabp1tm1Ipc mutation
(0 available);
any
Crabp1 mutation
(18 available)
Crabp2tm1Ipc mutation
(0 available);
any
Crabp2 mutation
(30 available)
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mortality/aging
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• ~9% of double homozygotes die before 6 weeks of age
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limbs/digits/tail
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• at P0-P42, 83% of double homozygotes show a forelimb outgrowth on the post-axial side of digit 5, either unilaterally (27%) or bilaterally (52%)
• this pots-axial digit outgrowth is of variable size and is also observed on all four limbs at a low frequency (4%)
• in severe cases, the digit rudiment bones are always floating
• in addition, 13% of double homozygotes display a pre-axial digit outgrowth in their hindlimbs, consisting of two bones not fully separated by a joint
• retinoic acid (RA) excess treatment in utero fails to increase the frequency of digit outgrowth, indicating normal sensitivity of double mutant embryos to RA excess
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hearing/vestibular/ear
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• contrary to expectation, E18.5 double homozygotes show normal cochlear morphology with no structural changes at the level of the organ of Corti relative to wild-type mice
• in addition, double homozygotes show no significant differences in ABR thresholds and latencies or DPOAEs relative to wild-type mice, indicating normal auditory function
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Analysis Tools