Phenotypes associated with this allele

• Allele Symbol: Tg(UcpDta)1Kz
• Allele Name: transgene insertion 1, Leslie P Kozak
• Allele ID: MGI:2183746
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(APOB)11Rub/0 Tg(UcpDta)1Kz/0	involves: C57BL/6J * FVB/N	MGI:2385750
tg2	Tg(UcpDta)1Kz/0	FVB/N-Tg(UcpDta)1Kz/J	MGI:4429478
tg3	Tg(UcpDta)1Kz/?	involves: FVB/N	MGI:2385751

Genotype
MGI:2385750

cx1

• Allelic Composition: Tg(APOB)11Rub/0; Tg(UcpDta)1Kz/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:73122 )

• on a high-fat, Western diet by 10 weeks of age, males are significantly heavier than Tg(APOB)11Rub and wild-type controls

homeostasis/metabolism

abnormal glucose homeostasis ( J:73122 )

increased circulating insulin level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma insulin levels

• however, fasting plasma glucose and free fatty acid levels do not vary from controls

insulin resistance ( J:73122 )

• males, but not females, are insulin resistant; males are impaired in their ability to clear exogenously administered glucose

abnormal lipid homeostasis ( J:73122 )

• males display a human-like dyslipidemia

• males exhibit increased synthesis and secretion of very low density lipoprotein (VLDL) triglycerides

• males exhibit increased apolipoprotein B (apoB) secretion rates

decreased circulating HDL cholesterol level ( J:73122 )

• HDL cholesterol is significantly reduced relative to Tg(APOB)11Rub mice

increased circulating cholesterol level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma total cholesterol concentrations

increased circulating LDL cholesterol level ( J:73122 )

• LDL cholesterol is increased relative to Tg(APOB)11Rub mice

increased circulating triglyceride level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma triglyceride concentrations

• IDL/LDL triglyceride levels are increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:78211

Genotype
MGI:4429478

tg2

• Allelic Composition: Tg(UcpDta)1Kz/0
• Genetic Background: FVB/N-Tg(UcpDta)1Kz/J

homeostasis/metabolism

impaired glucose tolerance ( J:129848 )

• mice exhibit impaired glucose tolerance compared with wild-type mice

• however, inhibition of fatty acid oxidation improves glucose tolerance

Genotype
MGI:2385751

tg3

• Allelic Composition: Tg(UcpDta)1Kz/?
• Genetic Background: involves: FVB/N

growth/size/body

increased body weight ( J:78211 )

• by 27 weeks, mice were nearly double the weight of controls

obese ( J:78211 )

• evident at 16 days of age and progressive

adipose tissue

decreased brown adipose tissue amount ( J:78211 )

• lacked brown adipose tissue

increased percent body fat/body weight ( J:78211 )

• by 19 weeks, mice had greater than 50% body fat

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:78211 )

N • normal corticosterone levels

abnormal glucose homeostasis ( J:78211 )

hyperglycemia ( J:78211 )

increased circulating insulin level ( J:78211 )

• hyperinsulinemia

insulin resistance ( J:78211 )

abnormal lipid homeostasis ( J:78211 )

increased circulating cholesterol level ( J:78211 )

• hypercholesterolemia

increased circulating triglyceride level ( J:78211 , J:147417 )

• hypertriglyceridemia (J:78211)

• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1 (J:147417)

hyperlipidemia ( J:78211 )

behavior/neurological

polyphagia ( J:78211 )

• beginning at 5-7 weeks

nervous system

nervous system phenotype ( J:78211 )

N • histologically normal hypothalamus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:78211