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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ncoa2tm1.1Ipc
targeted mutation 1.1, I Pierre Chambon
MGI:2183799
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:3716551
cn2
 		Ncoa1tm1Bwo/Ncoa1tm1Bwo
Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:3716555


Genotype
MGI:3716551
cn1
Allelic
Composition		 Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa2tm1.1Ipc mutation (0 available); any Ncoa2 mutation (76 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal decidualization ( J:117006 )
• uterus displays only partial decidual response to the deciduogenic stimulus estradiol + progesterone

reproductive system
reproductive system phenotype ( J:117006 )
N
• gonadotropin-treated ovaries ovulate comparably to wild-type, showing similar oocyte production
• epithelial proliferation in estradiol-treated ovarectomized uteri from mutants is similar to wild-type
abnormal decidualization ( J:117006 )
• uterus displays only partial decidual response to the deciduogenic stimulus estradiol + progesterone
failure of embryo implantation ( J:117006 )
• implantation sites are absent at 5.5 days post-coitum
female infertility ( J:117006 )
• females are infertile, despite normal mating behavior and presence of copulatory plugs; no litters were produced during six months of observation

endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:117006 )
• after a 3-week estradiol + progesterone treatment regime, full ductal side-branching and alveogenesis does not occur in mutant mammary glands in contrast to wild-type

integument
abnormal branching of the mammary ductal tree ( J:117006 )
• after a 3-week estradiol + progesterone treatment regime, full ductal side-branching and alveogenesis does not occur in mutant mammary glands in contrast to wild-type




Genotype
MGI:3716555
cn2
Allelic
Composition		 Ncoa1tm1Bwo/Ncoa1tm1Bwo
Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa1tm1Bwo mutation (0 available); any Ncoa1 mutation (169 available)
Ncoa2tm1.1Ipc mutation (0 available); any Ncoa2 mutation (76 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal decidualization ( J:117006 )
• uterus fails to display any decidual response upon stimulation

embryo
abnormal decidualization ( J:117006 )
• uterus fails to display any decidual response upon stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory