embryo
• uterus displays only partial decidual response to the deciduogenic stimulus estradiol + progesterone
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reproductive system
N |
• gonadotropin-treated ovaries ovulate comparably to wild-type, showing similar oocyte production
• epithelial proliferation in estradiol-treated ovarectomized uteri from mutants is similar to wild-type
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• uterus displays only partial decidual response to the deciduogenic stimulus estradiol + progesterone
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• implantation sites are absent at 5.5 days post-coitum
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• females are infertile, despite normal mating behavior and presence of copulatory plugs; no litters were produced during six months of observation
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endocrine/exocrine glands
• after a 3-week estradiol + progesterone treatment regime, full ductal side-branching and alveogenesis does not occur in mutant mammary glands in contrast to wild-type
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integument
• after a 3-week estradiol + progesterone treatment regime, full ductal side-branching and alveogenesis does not occur in mutant mammary glands in contrast to wild-type
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