Phenotypes associated with this allele

• Allele Symbol: Tg(APOB)11Rub
• Allele Name: transgene insertion 11, Edward M Rubin
• Allele ID: MGI:2183814
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(APOB)11Rub/0 Tg(UcpDta)1Kz/0	involves: C57BL/6J * FVB/N	MGI:2385750
tg2	Tg(APOB)11Rub/?	involves: FVB	MGI:2385623

Genotype
MGI:2385750

cx1

• Allelic Composition: Tg(APOB)11Rub/0; Tg(UcpDta)1Kz/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:73122 )

• on a high-fat, Western diet by 10 weeks of age, males are significantly heavier than Tg(APOB)11Rub and wild-type controls

homeostasis/metabolism

abnormal glucose homeostasis ( J:73122 )

increased circulating insulin level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma insulin levels

• however, fasting plasma glucose and free fatty acid levels do not vary from controls

insulin resistance ( J:73122 )

• males, but not females, are insulin resistant; males are impaired in their ability to clear exogenously administered glucose

abnormal lipid homeostasis ( J:73122 )

• males display a human-like dyslipidemia

• males exhibit increased synthesis and secretion of very low density lipoprotein (VLDL) triglycerides

• males exhibit increased apolipoprotein B (apoB) secretion rates

decreased circulating HDL cholesterol level ( J:73122 )

• HDL cholesterol is significantly reduced relative to Tg(APOB)11Rub mice

increased circulating cholesterol level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma total cholesterol concentrations

increased circulating LDL cholesterol level ( J:73122 )

• LDL cholesterol is increased relative to Tg(APOB)11Rub mice

increased circulating triglyceride level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma triglyceride concentrations

• IDL/LDL triglyceride levels are increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:78211

Genotype
MGI:2385623

tg2

• Allelic Composition: Tg(APOB)11Rub/?
• Genetic Background: involves: FVB

homeostasis/metabolism

increased circulating cholesterol level ( J:78212 )

• non-HDL plasma levels are increased (98 mg/dl compared to 23 mg/dl in wild-type mice)

increased circulating LDL cholesterol level ( J:78212 )

• plasma LDL is increased greater than 4-fold compared to in wild-type mice