All Phenotypes Mapk3<tm1Gpg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapk3^tm1Gpg
targeted mutation 1, Gilles Pages
MGI:2183906

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk3^tm1Gpg/Mapk3^tm1Gpg	involves: 129	MGI:3042020
hm2	Mapk3^tm1Gpg/Mapk3^tm1Gpg	involves: 129/Sv * C57BL/6	MGI:3042021
hm3	Mapk3^tm1Gpg/Mapk3^tm1Gpg	involves: 129/Sv * C57BL/6 * CD-1	MGI:4820404
cn4	Mapk1^tm2Melo/Mapk1^tm2Melo Mapk3^tm1Gpg/Mapk3^tm1Gpg	involves: 129	MGI:4820403
cn5	Mapk1^tm1.1Hed/Mapk1^tm1.1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129	MGI:5508241
cn6	Mapk1^tm2Moga/Mapk1^tm2Moga Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Mx1-cre)1Cgn/?	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA	MGI:3797232
cn7	Kras^tm1Bbd/Kras⁺ Mapk3^tm1Gpg/Mapk3^tm1Gpg	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:5508237
cn8	Kras^tm1Bbd/Kras⁺ Mapk1^tm1.1Hed/Mapk1^tm1.1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg	involves: 129/Sv * 129S1/Sv * 129X1/SvJ	MGI:5508240
cn9	Mapk3^tm1Gpg/Mapk3⁺ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0	involves: 129/Sv * C3H * C57BL/6 * FVB/N	MGI:3822163
cn10	Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0	involves: 129/Sv * C3H * C57BL/6 * FVB/N	MGI:3822162
cn11	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3687236
cn12	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Lck-cre)1Cwi/0	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3687234
cn13	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0 Tg(TcrAND)53Hed/0	involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:3687238
cx14	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(TcraTcrb)1100Mjb/0	involves: 129/Sv * C57BL/6	MGI:3687241
cx15	Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Myh6-Map2k1*)1Jmol/0	involves: 129/Sv * FVB/N	MGI:3851930
cx16	Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Myh7-Ptpn11*Q79R)11Rbns/0	involves: 129/Sv * FVB/N	MGI:3822148

Allelic Composition	Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:124903 )

hematopoietic system

decreased T cell proliferation ( J:58468 )

• there is a 80 - 90% decrease in thymocyte proliferation following T cell receptor activation in mutants compared to wild-type mice

decreased T cell number ( J:58468 )

• reduced numbers of single positive mature T cells are seen in mutants compared to wild-type mice however, thymus cellularity is unaffected

immune system

decreased T cell proliferation ( J:58468 )

• there is a 80 - 90% decrease in thymocyte proliferation following T cell receptor activation in mutants compared to wild-type mice

decreased T cell number ( J:58468 )

• reduced numbers of single positive mature T cells are seen in mutants compared to wild-type mice however, thymus cellularity is unaffected

cardiovascular system

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

• mice show no reduction in exercise-induced (swimming) cardiac hypertrophy compared to that seen in wild-type mice

cellular

decreased T cell proliferation ( J:58468 )

• there is a 80 - 90% decrease in thymocyte proliferation following T cell receptor activation in mutants compared to wild-type mice

growth/size/body

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

• mice show no reduction in exercise-induced (swimming) cardiac hypertrophy compared to that seen in wild-type mice

Allelic Composition	Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal active avoidance behavior ( J:89788 )

• mutant mice learn the task significantly faster than wild-type mice

abnormal passive avoidance behavior ( J:89788 )

• mutants have significantly better long term retention (longer step through latencies at 24 hours after training) than wild-type mice

increased locomotor activity ( J:89788 )

• mutant mice have a tendency to be more active in the open field than wild-type mice

nervous system

reduced long-term potentiation ( J:89788 )

• the long term potentiation induced by theta burst stimulation is significantly smaller in mutants than in wild-type mice

cellular

cellular phenotype ( J:162580 )

N	• Background Sensitivity: mouse embryonic fibroblasts (MEFs) exhibit normal proliferation unlike MEFs from mice on a CD-1 background

muscle

muscle phenotype ( J:190460 )

N	• at 2 months, mice exhibit normal skeletal muscle tissue

Allelic Composition	Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129/Sv * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:162580 )

N	• mice are born at normal Mendelian ratios

cellular

decreased fibroblast proliferation ( J:162580 )

• Background Sensitivity: modestly in mouse embryonic fibroblasts (MEFs) unlike MEFs from a mouse on a C57BL/6 background

growth/size/body

growth/size/body region phenotype ( J:162580 )

N	• mice exhibit normal growth

Allelic Composition	Mapk1^tm2Melo/Mapk1^tm2Melo Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm2Melo mutation (0 available); any Mapk1 mutation (41 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:162580 )

• more mouse embryonic fibroblasts (MEF) exposed to a cre-expressing retroviral vector are in G0/G1 phase and fewer in S phase than MEF not exposed to cre

increased fibroblast apoptosis ( J:162580 )

• in mouse embryonic fibroblasts exposed to a cre-expressing retroviral vector

early cellular replicative senescence ( J:162580 )

• mouse embryonic fibroblasts (MEFs) exposed to a cre-expressing retroviral vector exhibit increased senescence compared with MEFs not exposed to cre

Allelic Composition	Mapk1^tm1.1Hed/Mapk1^tm1.1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1.1Hed mutation (0 available); any Mapk1 mutation (41 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172200 )

• mice fed a tamoxifen-containing diet show a deterioration of health and die within 3 weeks due to multiple organ failure

Allelic Composition	Mapk1^tm2Moga/Mapk1^tm2Moga Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm2Moga mutation (0 available); any Mapk1 mutation (41 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal pro-B cell morphology ( J:134528 )

• two weeks after Cre induction by pI-pC injection, the ratio of BP-1⁺HAS^high cells to BP-1⁺HAS^low cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells

• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase

abnormal pro-B cell differentiation ( J:134528 )

• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice

• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice

decreased pre-B cell number ( J:134528 )

• two weeks after Cre induction by pI-pC injection, pre-B cell (B220^lowIgM^-Cd43^-) numbers in the bone marrow are 7% of controls

• immature B cells (B220^lowIgM⁺Cd43^-) in the bone marrow are also reduced by a similar amount

hematopoietic system

abnormal pro-B cell morphology ( J:134528 )

• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase

abnormal pro-B cell differentiation ( J:134528 )

• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice

• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice

decreased pre-B cell number ( J:134528 )

• two weeks after Cre induction by pI-pC injection, pre-B cell (B220^lowIgM^-Cd43^-) numbers in the bone marrow are 7% of controls

• immature B cells (B220^lowIgM⁺Cd43^-) in the bone marrow are also reduced by a similar amount

Allelic Composition	Kras^tm1Bbd/Kras⁺ Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172200 )

• 50% survival at 46.3 weeks of age is seen following intratracheal instillation of Ad-Cre, a 20% increase in survival compared to single Kras mutants

neoplasm

increased lung non-small cell carcinoma incidence ( J:172200 )

• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes

respiratory system

increased lung non-small cell carcinoma incidence ( J:172200 )

Allelic Composition	Kras^tm1Bbd/Kras⁺ Mapk1^tm1.1Hed/Mapk1^tm1.1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Mapk1^tm1.1Hed mutation (0 available); any Mapk1 mutation (41 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172200 )

• following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), mutants show 50% survival at 63 weeks versus 48 weeks in single Kras mutants, a 40% increase in survival

neoplasm

decreased classified tumor incidence ( J:172200 )

• 6 months following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), only a few tumors are observed; tumors that are found express normal levels of Mapk1

Allelic Composition	Mapk3^tm1Gpg/Mapk3⁺ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129/Sv * C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142212 )

• all mice died by E14.5

cardiovascular system

increased atrioventricular cushion size ( J:142212 )

• endocardial cushion volume is increased compared to in wild-type mice but not as severely as in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice

liver/biliary system

hepatic necrosis ( J:142212 )

homeostasis/metabolism

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

integument

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

growth/size/body

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

Allelic Composition	Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129/Sv * C3H * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142212 )

• all mice died by E14.5

• however, Mendelian ratios of embryos are present at E13.5

cardiovascular system

cardiovascular system phenotype ( J:142212 )

N	• mice exhibit normal endocardial cushion size and rates of proliferation and apoptosis of endothelial and mesenchymal cushion cells

liver/biliary system

hepatic necrosis ( J:142212 )

homeostasis/metabolism

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

integument

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

growth/size/body

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (41 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes but there is still a substantial population of single positive thymocytes

immune system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes but there is still a substantial population of single positive thymocytes

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

small thymus ( J:113280 )

• some mice have very small thymuses (13 x 10⁶ cells) with few DN4 cells, but some have larger thymuses (115 x 10⁶ cells)

decreased thymocyte number ( J:113280 )

• total thymocyte number is decreased >3-fold compared to wild-type

increased double-positive T cell number ( J:113280 )

• mice have a substantial population of double-positive T cells

hematopoietic system

abnormal T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

small thymus ( J:113280 )

• some mice have very small thymuses (13 x 10⁶ cells) with few DN4 cells, but some have larger thymuses (115 x 10⁶ cells)

decreased thymocyte number ( J:113280 )

• total thymocyte number is decreased >3-fold compared to wild-type

increased double-positive T cell number ( J:113280 )

• mice have a substantial population of double-positive T cells

endocrine/exocrine glands

small thymus ( J:113280 )

• some mice have very small thymuses (13 x 10⁶ cells) with few DN4 cells, but some have larger thymuses (115 x 10⁶ cells)

decreased thymocyte number ( J:113280 )

• total thymocyte number is decreased >3-fold compared to wild-type

cellular

abnormal T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0 Tg(TcrAND)53Hed/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:113280 )

• positive selection is diminished significantly

abnormal T cell subpopulation ratio ( J:113280 )

• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 24 compared to 257 in non transgenic littermates

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• positive selection is diminished significantly

abnormal T cell subpopulation ratio ( J:113280 )

• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 24 compared to 257 in non transgenic littermates

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

hematopoietic system

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

endocrine/exocrine glands

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

Allelic Composition	Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Myh6-Map2k1*)1Jmol/0
Genetic Background	involves: 129/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:124903 )

• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

growth/size/body

cardiac hypertrophy ( J:124903 )

• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

Allelic Composition	Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Myh7-Ptpn11*Q79R)11Rbns/0
Genetic Background	involves: 129/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Myh7-Ptpn11*Q79R)11Rbns mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:123963 )

N	• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, heart weight, ventricular compaction, cardiac cell proliferation and heart function are normal

respiratory system

respiratory system phenotype ( J:123963 )

N	• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, lung weight is normal

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