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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k2tm1Bisu
targeted mutation 1, Bing Su
MGI:2183907
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k2tm1Bisu/Map3k2tm1Bisu Not Specified MGI:3580325


Genotype
MGI:3580325
hm1
Allelic
Composition		 Map3k2tm1Bisu/Map3k2tm1Bisu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k2tm1Bisu mutation (0 available); any Map3k2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:78072 )
• significant increase of apoptotic thymocytes in antibody stimulated mice
• increased DNA fragmentation in the thymus
increased T cell proliferation ( J:78072 )
• very vigorous activation and proliferation response to antibody stimulation
abnormal cytokine secretion ( J:78072 )
• more Il-2 and Ifn-gamma but less Il-4 produced by T cells

hematopoietic system
abnormal T cell activation ( J:78072 )
• significant increase of apoptotic thymocytes in antibody stimulated mice
• increased DNA fragmentation in the thymus
increased T cell proliferation ( J:78072 )
• very vigorous activation and proliferation response to antibody stimulation

cellular
increased T cell proliferation ( J:78072 )
• very vigorous activation and proliferation response to antibody stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory