Analysis Tools
neoplasm
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• found in about 65% of one year old mice, averaging about 1.5 tumors per mouse
• tumors appear first in the small intestine, then the large intestine, never in the stomach
• epithelial in origin, becoming invasive carcinomas in older mice
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cardiovascular system
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• fecal blood found as early as 6 months of age when gastrointestinal tumors can also be found
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digestive/alimentary system
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• fecal blood found as early as 6 months of age when gastrointestinal tumors can also be found
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• mice exhibit distorted and flattened structure of the epithelial cells
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• los of the mucus layer of the distal colon
• loss of lamina propria architecture
• the lamina propria shows an increase in total cells, CD4+ and CD8+ T lymphocytes and IgA-producing B cells
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• absent in the intestine
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• increase in crypt length, particularly in the distal colon
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• found in about 65% of one year old mice, averaging about 1.5 tumors per mouse
• tumors appear first in the small intestine, then the large intestine, never in the stomach
• epithelial in origin, becoming invasive carcinomas in older mice
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• mice exhibit bacteria on the epithelium and in crypts of the distal colon indicating compromised mucus barrier
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• intestinal epithelial cells exhibit decreased apoptosis
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• intestinal epithelial cells exhibit increased proliferation
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• mice exhibit cell infiltration and superficial epithelial erosions that are more pronounced at the distal end of the colon
• the colon lamina propria shows an increase in total cells, CD4+ and CD8+ T lymphocytes and IgA-producing B cells
• only a subset of mutants show signs of inflammation in the colon characterized by neutrophil infiltration in the colon lamina propria corresponds with decreased number of CD103+CD11b- dendritic cells and increased number of CD103+CD11b+ dendritic cells and CD103-CD11b+ macrophages in the colon
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• mice develop spontaneous colitis between 8 and 20 weeks of age
• mice exhibit a higher bacterial burden than controls in the colon and mesenteric lymph nodes due to compromised mucus barrier in the intestine
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endocrine/exocrine glands
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• increase in crypt length, particularly in the distal colon
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immune system
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• mice exhibit cell infiltration and superficial epithelial erosions that are more pronounced at the distal end of the colon
• the colon lamina propria shows an increase in total cells, CD4+ and CD8+ T lymphocytes and IgA-producing B cells
• only a subset of mutants show signs of inflammation in the colon characterized by neutrophil infiltration in the colon lamina propria corresponds with decreased number of CD103+CD11b- dendritic cells and increased number of CD103+CD11b+ dendritic cells and CD103-CD11b+ macrophages in the colon
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• mice develop spontaneous colitis between 8 and 20 weeks of age
• mice exhibit a higher bacterial burden than controls in the colon and mesenteric lymph nodes due to compromised mucus barrier in the intestine
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cellular
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• absent in the intestine
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• intestinal epithelial cells exhibit decreased apoptosis
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• epithelial cells in the intestinal mucosa migrate more rapidly
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• intestinal epithelial cells exhibit increased proliferation
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• in intestinal epithelial cells
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease | DOID:0050589 |
OMIM:PS266600 |
J:216831 | |
