Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cdc7tm1Hmas targeted mutation 1, Hisao Masai MGI:2183930 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant embryos die between E3.5-E6.5
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• blastocysts grown in culture exhibit a smaller inner cell mass at E6 that continues to diminish in size such that by E8.5 it has disappeared
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant embryos die around E8.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 75% of mice born die within 3 days
• less than 25% survived to adulthood
• survivors have a normal life span
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• very few mice born
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• mouse embryo fibroblast growth slowed considerably
• fewer cells in S phase
• larger numbers of cells in G0 or G1
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• total absence of post meiotic cells
• failure in prophase I probably in zygotene stage
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• reduced rate of DNA replication
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• lack oocytes and follicles
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• ovaries are small and grossly malformed
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• reduced number of seminiferous tubules
• reduced spermatogonia
• degenerating primary spermatocytes
• high levels of apoptosis
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• mice that survive to adulthood are 50-55% normal size
• major organs are proportional
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| N |
• thymic and periferral lymphocytes normal
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• tail flexion anomalies similar to curly-tail (ct) mice
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• lack oocytes and follicles
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• ovaries are small and grossly malformed
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• total absence of post meiotic cells
• failure in prophase I probably in zygotene stage
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• reduced number of seminiferous tubules
• reduced spermatogonia
• degenerating primary spermatocytes
• high levels of apoptosis
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• reduced rate of DNA replication
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• testes remain small
• mouse embryo fibroblast proliferation and DNA synthesis essentially normal
• body weights normal
• males were fertile
• spermatogenesis restored
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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