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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad54ltm1Jhjh
targeted mutation 1, Jan H J Hoeijmakers
MGI:2183934
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad54ltm1Jhjh/Rad54ltm1Jhjh involves: 129P2/OlaHsd MGI:4429605
hm2
 		Rad54ltm1Jhjh/Rad54ltm1Jhjh involves: 129P2/OlaHsd * C57BL/6 MGI:3040059
cx3
 		Prkdctm1Get/Prkdc+
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3040060
cx4
 		Prkdctm1Get/Prkdctm1Get
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3040061
cx5
 		Rad54btm1Roka/Rad54btm1Roka
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3618235
cx6
 		Rad52tm1Aps/Rad52tm1Aps
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3850728


Genotype
MGI:4429605
hm1
Allelic
Composition		 Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:47993 )
N
• somatic hypermutation rates in memory B cells are normal




Genotype
MGI:3040059
hm2
Allelic
Composition		 Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice

cellular
abnormal chromosome morphology ( J:101697 )
• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice
abnormal cell physiology ( J:83373 )
• mice were sensitive to DNA crosslinking agents and to ionizing radiation
• there was no affect on somatic instability
increased cellular sensitivity to gamma-irradiation ( J:105544 )
• derived ES cells show a 2-3X increase in sensitivity to ionizing radiation

hematopoietic system
abnormal definitive hematopoiesis ( J:101697 )
• following treatment with X-rays, mice exhibit a small hematopoietic depression unlike similarly treated wild-type mice

immune system
immune system phenotype ( J:39642 )
N
• mice were specifically examined for an effect on V(D)J recombination and none was found
• at the same time, no other gross abnormalities were observed

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice




Genotype
MGI:3040060
cx3
Allelic
Composition		 Prkdctm1Get/Prkdc+
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdctm1Get mutation (3 available); any Prkdc mutation (418 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:84801 )
• end to end chromosome fusions occur in about 1.6 out of 100 metaphases
• chromosome fusions involve random chromosomes
decreased telomere length ( J:84801 )
• telomeres are significantly shorter than in doubly heterozygous controls but there is always a detectable telomere




Genotype
MGI:3040061
cx4
Allelic
Composition		 Prkdctm1Get/Prkdctm1Get
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdctm1Get mutation (3 available); any Prkdc mutation (418 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:84801 )
• end to end chromosome fusions occur in about 3 out of 50 metaphases
• chromosome fusions involve random chromosomes




Genotype
MGI:3618235
cx5
Allelic
Composition		 Rad54btm1Roka/Rad54btm1Roka
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54btm1Roka mutation (0 available); any Rad54b mutation (143 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )
• mice extremely sensitive to mitomycin C, 100% mortality when given a 7.5mg/kg dose

cellular
abnormal cell physiology ( J:105544 )
• virtually no homologous recombination occurs in derived ES cells
increased cellular sensitivity to gamma-irradiation ( J:105544 )
• derived ES cells show a 2-3X increase in sensitivity to ionizing radiation which is not seen in the mice themselves

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )
• mice extremely sensitive to mitomycin C, 100% mortality when given a 7.5mg/kg dose

hematopoietic system
abnormal erythrocyte morphology ( J:105544 )
• much higher numbers of micronuclei after treatment with mitomycin C




Genotype
MGI:3850728
cx6
Allelic
Composition		 Rad52tm1Aps/Rad52tm1Aps
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation (1 available); any Rad52 mutation (18 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes

hematopoietic system
abnormal definitive hematopoiesis ( J:101697 )
• following treatment with X-rays, mice exhibit severe hematopoietic depression compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes

cellular
abnormal chromosome morphology ( J:101697 )
• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory