Analysis Tools
immune system
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• thymus lacks distinct cortico-medullary junction
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• thymus is small with 10 to 50-fold fewer cells than control
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• VK-JK2 rearrangements are severely reduced
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• D-JH4 and VH7193-DJH4 rearrangements are severely reduced
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• B cell development is arrested at pro-B cell stage (B220+ CD43+ IgM-)
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• Valpha8-Jalpha50 rearrangements are undetectable
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• rearrangements of Vbeta8-DJbeta2.6 are rare in thymocytes and detected only at low levels in the spleen
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• coding join formation for Ddelta2-Jdelta1 is detectable by PCR, but Vdelta1-DJdelta1 is undetectable in thymocytes
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• thymocytes display an accumulation of pre-T cells (CD44- CD25+)
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• accumulation of double positive T cells is highest in 8 day old mice and represents 43-45% of total thymocytes
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• mature T cells are not detected in periphery of 2 week old animals
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• splenic population of Mac-1+ (myeloid) and DX5+ (natural killer) cells is increased
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• splenic population of single positive T cells is less than 5% in spleen of 6 week old mice
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• spleen is small with 5 fold fewer cells than control
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• splenic white pulp nodules are reduced in size
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• serum IgM cannot be detected in 2 week old mice
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• lymph nodes are reduced in size
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hematopoietic system
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• thymus lacks distinct cortico-medullary junction
|
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• thymus is small with 10 to 50-fold fewer cells than control
|
|
• VK-JK2 rearrangements are severely reduced
|
|
• D-JH4 and VH7193-DJH4 rearrangements are severely reduced
|
|
• B cell development is arrested at pro-B cell stage (B220+ CD43+ IgM-)
|
|
• Valpha8-Jalpha50 rearrangements are undetectable
|
|
• rearrangements of Vbeta8-DJbeta2.6 are rare in thymocytes and detected only at low levels in the spleen
|
|
• coding join formation for Ddelta2-Jdelta1 is detectable by PCR, but Vdelta1-DJdelta1 is undetectable in thymocytes
|
|
• mature T cells are not detected in periphery of 2 week old animals
|
|
• splenic population of Mac-1+ (myeloid) and DX5+ (natural killer) cells is increased
|
|
• thymocytes display an accumulation of pre-T cells (CD44- CD25+)
|
|
• accumulation of double positive T cells is highest in 8 day old mice and represents 43-45% of total thymocytes
|
|
• splenic population of single positive T cells is less than 5% in spleen of 6 week old mice
|
|
• spleen is small with 5 fold fewer cells than control
|
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• splenic white pulp nodules are reduced in size
|
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• serum IgM cannot be detected in 2 week old mice
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cellular
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• MEFs exhibit radiosensitivity
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endocrine/exocrine glands
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• thymus lacks distinct cortico-medullary junction
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• thymus is small with 10 to 50-fold fewer cells than control
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