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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad52tm1Aps
targeted mutation 1, Albert Pastink
MGI:2383953
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad52tm1Aps/Rad52tm1Aps involves: 129P2/OlaHsd * C57BL/6 MGI:3850719
cx2
 		Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3850721
cx3
 		Rad52tm1Aps/Rad52tm1Aps
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3850728


Genotype
MGI:3850719
hm1
Allelic
Composition		 Rad52tm1Aps/Rad52tm1Aps
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation (1 available); any Rad52 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:50357 )
N
• mice exhibit normal lymphocyte development and Ig class switching

reproductive system
reproductive system phenotype ( J:50357 )
N
• mice exhibit normal reproductive system morphology and physiology




Genotype
MGI:3850721
cx2
Allelic
Composition		 Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (170 available)
Rad52tm1Aps mutation (1 available); any Rad52 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:90941 )
• median survival is 33 weeks compared to 16 weeks for Atmtm1Awb homozygotes

neoplasm
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors
decreased lymphoma incidence ( J:90941 )
• unlike in Atmtm1Awb homozygotes, mice rarely develop T cell lymphomas

immune system
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors

growth/size/body
decreased body weight ( J:90941 )
• 25%

hematopoietic system
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors

homeostasis/metabolism

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:90941 )
• mice develop thymic tumors




Genotype
MGI:3850728
cx3
Allelic
Composition		 Rad52tm1Aps/Rad52tm1Aps
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad52tm1Aps mutation (1 available); any Rad52 mutation (18 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes

hematopoietic system
abnormal definitive hematopoiesis ( J:101697 )
• following treatment with X-rays, mice exhibit severe hematopoietic depression compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes

cellular
abnormal chromosome morphology ( J:101697 )
• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54ltm1Jhjh homozygotes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory