Phenotypes associated with this allele

• Allele Symbol: Fdft1^tm1Yma
• Allele Name: targeted mutation 1, Nobuhiro Yamada
• Allele ID: MGI:2383989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fdft1^tm1Yma/Fdft1^tm1Yma	involves: 129S7/SvEvBrd	MGI:3580013

Genotype
MGI:3580013

hm1

• Allelic Composition: Fdft1^tm1Yma/Fdft1^tm1Yma
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation and defective neural tube closure in Fdft1^tm1Yma/Fdft1^tm1Yma embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:58231 )

• the lethal phenotype was not rescued by supplementing the dams either with dietary squalene or cholesterol

• die around E9.5-10.5 with severe growth retardation and defective neural tube closure

growth/size/body

embryonic growth retardation ( J:58231 )

nervous system

incomplete rostral neuropore closure ( J:58231 )

• often exhibit open head folds at E10.5

embryo

embryonic growth retardation ( J:58231 )

incomplete rostral neuropore closure ( J:58231 )

• often exhibit open head folds at E10.5