About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fcer1gtm1Tks
targeted mutation 1, Takashi Saito
MGI:2384004
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fcer1gtm1Tks/Fcer1gtm1Tks C57BL/6-Fcer1gtm1Tks MGI:4360275
hm2
Fcer1gtm1Tks/Fcer1gtm1Tks involves: C57BL/6 MGI:4360109
hm3
Fcer1gtm1Tks/Fcer1gtm1Tks involves: C57BL/6J MGI:5528882
cx4
Faslpr/Faslpr
Fcer1gtm1Tks/Fcer1gtm1Tks
MRL.Cg-Fcer1gtm1Tks Faslpr MGI:4360203


Genotype
MGI:4360275
hm1
Allelic
Composition
Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic
Background
C57BL/6-Fcer1gtm1Tks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Tks mutation (1 available); any Fcer1g mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice are resistant to hemolytic anemia induced by self-binding IgG2a antibodies
• no protection is seen with pathogenic self-binding IgA antibodies

hematopoietic system
• mice are resistant to hemolytic anemia induced by self-binding IgG2a antibodies
• no protection is seen with pathogenic self-binding IgA antibodies




Genotype
MGI:4360109
hm2
Allelic
Composition
Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Tks mutation (1 available); any Fcer1g mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• CD4+ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro
• macrophages have lost the ability to ingest target cells coated in IgG

mortality/aging
• mice are resistant to an induced glumoronephritis disease caused by administration of anti-glomerular basement membrane antibodies (anti-GBM Ab)
• wild-type controls are dead by 14 days after administration while all of the mutant mice survive

homeostasis/metabolism
• production of the cytokines/chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2) and IL-6 upon stimulation with acylated phosphatidyl-inositol mannosides is lower in peritoneal exudate cells

immune system
• CD4+ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro
• mice have lower titers of antigen-specific IgG1 2 weeks after immunization compared to controls
• mice have lower titers of antigen-specific IgG2a 2 weeks after immunization compared to controls
• mice have lower titers of antigen-specific IgG2b 2 weeks after immunization compared to controls
• mice have lower titers of antigen-specific IgG3 2 weeks after immunization compared to controls
• NK cells fail to activate and secrete IFN-gamma in response to KLR activation
• response is normal when IL-2 is used to stimulate the cells
• NK cells do not have increased cytotoxicity against target cells coated with an anti-KLR antibody
• CD4+ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro
• these T cells also have reduced secretion of IL-2 and IFN-gamma
• NKT cells fail to activate and secrete IFN-gamma in response to KLR activation
• response is normal when TCR stimulation is used
• bone marrow-derived macrophages fail to respond to Clec4e (Mincle) stimulation
• macrophages have lost the ability to ingest target cells coated in IgG
• production of the cytokines/chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2) and IL-6 upon stimulation with acylated phosphatidyl-inositol mannosides is lower in peritoneal exudate cells
• CD4+ T cells have normal primary responses suggesting lower T cell activity from immunized mice is a failure in antigen presentation
• bone marrow-derived macrophages fail to secrete MIP-2 to Clec4e (Mincle) stimulation
• natural killer and natural killer T cells fail to secrete IFN-gamma in response to KLR stimulation (J:111365)
• CD4+ T cells isolated from antigen-challenged mice have reduced secretion of IFN-gamma in response to antigen encounter in vitro (J:112160)
• CD4+ T cells isolated from antigen-challenged mice have reduced secretion of IL-2 in response to antigen encounter in vitro
• macrophages have lost the ability to ingest target cells coated in IgG
• footpad swelling of antigen-sensitized mice is one-third less than controls 2 weeks after antigen challenge and one-half less than controls after 10 weeks

hematopoietic system
• CD4+ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro
• mice have lower titers of antigen-specific IgG1 2 weeks after immunization compared to controls
• mice have lower titers of antigen-specific IgG2a 2 weeks after immunization compared to controls
• mice have lower titers of antigen-specific IgG2b 2 weeks after immunization compared to controls
• mice have lower titers of antigen-specific IgG3 2 weeks after immunization compared to controls
• NK cells fail to activate and secrete IFN-gamma in response to KLR activation
• response is normal when IL-2 is used to stimulate the cells
• NK cells do not have increased cytotoxicity against target cells coated with an anti-KLR antibody
• CD4+ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro
• these T cells also have reduced secretion of IL-2 and IFN-gamma
• NKT cells fail to activate and secrete IFN-gamma in response to KLR activation
• response is normal when TCR stimulation is used
• bone marrow-derived macrophages fail to respond to Clec4e (Mincle) stimulation
• macrophages have lost the ability to ingest target cells coated in IgG




Genotype
MGI:5528882
hm3
Allelic
Composition
Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Tks mutation (1 available); any Fcer1g mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice treated with oil-in-water emulsion of trehalose-6,60'-dimycolate (TDM)

immune system
• TDM-treated mice exhibit less of an increase in draining lymph nodes dendritic cells compared with wild-type mice
• bone marrow-derived dendritic cells and macrophages stimulated with platelets coated in trehalose-6,60'-dimycolate (TDM) or zymosan exhibit reduced MIP-2 secretion compared with wild-type cells
• TDM-treated bone marrow dendritic cells co-cultured with OT-II cells and OVA323-339 or OVA257-264 peptide or ovalbumin protein fail to exhibit an increase in IFN-gamma and IL17 unlike wild-type cells
• TDM-treated bone marrow dendritic cells co-cultured with OT-II cells and OVA323-339 peptide fail to exhibit an increase in IFN-gamma and IL17 unlike wild-type cells
• in bone marrow-derived dendritic cells and macrophages stimulated with platelets coated in TDM or zymosan

homeostasis/metabolism
• in mice treated with oil-in-water emulsion of trehalose-6,60'-dimycolate (TDM)
• mice treated with TDM exhibit are resistance to lung inflammation, granuloma and lethality unlike wild-type mice

hematopoietic system
• TDM-treated mice exhibit less of an increase in draining lymph nodes dendritic cells compared with wild-type mice




Genotype
MGI:4360203
cx4
Allelic
Composition
Faslpr/Faslpr
Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic
Background
MRL.Cg-Fcer1gtm1Tks Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Fcer1gtm1Tks mutation (1 available); any Fcer1g mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice diet of renal failure by 65 weeks of age with a 50% survival rate at a median age of 32-34 weeks similar to MRL-Faslpr mice

immune system
N
• MRL-Fas mice homozygous for the Fcer1gtm1Tks allele still develop glomerulonephritis in a similar manner as MRL-Faslpr mice carrying the wild-type Fcer1gtm1Tks allele
• necrotizing vasculitis with mononuclear cell infiltration, vessel wall destruction, and occasional thrombosis are observed in the interlobular arteries of the kidney
• necrotizing vasculitis of the pulmonary arteries, with mononuclear cell infiltration and vessel wall destruction occur
• spleen weight is 7- to 8-fold greater than C57BL/6 controls but is similar to MRL-Faslpr mice
• a double-negative, B220+ T cell population accumulates in the spleen and lymph nodes similar to MRL-Faslpr mice
• IgG levels are elevated compared to C57BL/6 controls but are similar to MRL-Faslpr mice
• extravasation does not occur in mice as occurs in controls when iv injected with OVA and intradermally injected with rabbit anti-OVA IgG
• anti-DNA Iglevels are elevated compared to C57BL/6 controls but are similar to MRL-Faslpr mice
• mice develop diffuse proliferative GN with mononuclear cell infiltration, mesangial and endothelial cell proliferation, and crescent formation after 16 weeks of age similar to MRL-Faslpr mice
• proteinuria, followed by renal failure, develops in all mice

renal/urinary system
• endothelial cell proliferation is noted after 16 weeks of age
• mesangial cell proliferation is noted after 16 weeks of age
• mesangial and endothelial cell proliferation after 16 weeks of age
• urinary protein concentrations increase with age similar to MRL-Faslpr mice
• mice develop diffuse proliferative GN with mononuclear cell infiltration, mesangial and endothelial cell proliferation, and crescent formation after 16 weeks of age similar to MRL-Faslpr mice
• proteinuria, followed by renal failure, develops in all mice
• crescent formation is noted after 16 weeks of age
• mice die of renal failure by 65 weeks of age similar to MRL-Faslpr mice

homeostasis/metabolism
• urinary protein concentrations increase with age similar to MRL-Faslpr mice

cardiovascular system
• endothelial cell proliferation is noted after 16 weeks of age
• various forms of medium and small vessel vasculitis occur similar to MRL-Faslpr mice
• necrotizing vasculitis with mononuclear cell infiltration, vessel wall destruction, and occasional thrombosis are observed in the interlobular arteries of the kidney
• necrotizing vasculitis of the pulmonary arteries, with mononuclear cell infiltration and vessel wall destruction occur

hematopoietic system
• spleen weight is 7- to 8-fold greater than C57BL/6 controls but is similar to MRL-Faslpr mice
• a double-negative, B220+ T cell population accumulates in the spleen and lymph nodes similar to MRL-Faslpr mice
• IgG levels are elevated compared to C57BL/6 controls but are similar to MRL-Faslpr mice

cellular
• mesangial cell proliferation is noted after 16 weeks of age
• mesangial and endothelial cell proliferation after 16 weeks of age

growth/size/body
• spleen weight is 7- to 8-fold greater than C57BL/6 controls but is similar to MRL-Faslpr mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory