Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fgrtm1Hev targeted mutation 1, Harold E Varmus MGI:2384040 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit partially reduced hemorrhage compared to the thrombohemorrhagic vasculitis observed in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• stimulated natural killer (NK) cells produce more NKR-P1C-induced IFN-gamma than wild-type NK cells
• however, INF-gamma production by NK T cells is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil migration is normal
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced numbers of filopodia and increased lamellopodia related membrane structures
• abnormal F-actin organization
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• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits
• impaired migration
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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• impaired ability to resolve infection with Listeria monocytogenes
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• angiogenic responses to Cxcl1 and Cxcl2 are disrupted
• neutrophile responses normal but they fail to release VEGF-A in response to Cxcl1 and Cxcl2
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• reduced numbers of filopodia and increased lamellopodia related membrane structures
• abnormal F-actin organization
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• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits
• impaired migration
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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