Analysis Tools
mortality/aging
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• majority of pups with paternally-derived deletion of the region die in the neonatal period
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• 50% of paternal heterozygotes die by day 12 and 78% die before weaning
• when males with the maternally-inherited deletion are crossed to C57BL/6J males, ~80% lethality is observed
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growth/size/body
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• ~50% of offspring of male chimeras mated to wild-type C57BL/6J females are runted and relatively weak; these pups inherited the deletion from chimeric male parent
• pups inheriting the deletion paternally exhibit severe growth retardation compared to controls
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• affected pups are underweight (1.18g at 6-12 hours of age) vs wild-type (1.36g)
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behavior/neurological
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• pups inheriting the deletion paternally are able to suckle but amount of milk in stomachs is less than in wild-type controls
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• pups inheriting the deletion paternally display an impaired righting response when placed on their backs
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bradykinesia
(
J:56617
)
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• pups inheriting the deletion paternally exhibit decreased movement
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muscle
normal phenotype
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• pups inheriting the deletion from the female parent are normal and viable (ie pups from female chimeras bred to wild-type C57BL/6J males)
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